Lecture, LUCL Colloquium - Series '24/'25

As a result of an increased life expectancy, more people suffer from chronic diseases and discomfort. Elderly patients may have multiple diseases simultaneously, with concomitant multiple medications.

Cardiovascular disease is the leading cause of death worldwide.

PhD defence

Three Psychology students will present a poster of their thesis research on Alzheimer’s and dementia at the international conference AAIC Neuroscience Next. ‘I remind myself to recognise - without fear or shame - when I don't know something.’

The objective of the Next Generation ImmunoDermatology project (funding NWO, program NWA-ORC) is to deep profile the immune-mediated inflammatory diseases: i) atopic dermatitis (AD), ii) cutaneous lupus erythematosus (CLE) iii) chronic spontaneous urticaria (CSU) iv) hidradenitis suppurativa (HS) v)…

Nobody is better qualified to tell you what it is like to work at Leiden University than the employees themselves. Watch the videos and meet your future colleagues. They will be happy to share their experiences with you.

It is difficult to imagine a society other than a hierarchical nation-state. This is in part because we neglect alternative forms from the past, argues archaeologist Lewis Borck in the Journal of Contemporary Archaeology.

The Aging and Immunity group is led by Dr. Amanda Foks. In this group we aim to investigate how aged immune cells contribute to atherosclerosis and identify novel therapeutic targets and strategies to extend health span and inhibit cardiovascular disease.

How can you use robots and automatic recognition of microscopic images to test the effect of drugs exceptionally quickly?

The company Azafaros was established in 2018 to translate innovative science from Leiden University and Amsterdam University Medical Center into novel disease-modifying treatment modalities for rare genetic metabolic disorders such as lysosomal storage diseases.

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Overkleeft

How can we extend the drug residence time to combat diseases more effectively?

The Horizon 2020 project CoSTREAM aims to improve our understanding of the co-occurrence of stroke and Alzheimer’s disease. It has long been known that both diseases share underlying causes, but their exact interaction or link is not fully understood. CoSTREAM combines multiple factors to identify and…

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

Atherosclerosis is a chronic inflammatory disease affecting millions of people world-wide.

Corinne Hofman (Professor in Caribbean Archaeology) has been awarded 15 million euro by the EU for her archaeological research on the colonisation of the Americas. She will lead the ‘NEXUS 1492’ project together with colleagues Davies (VU), Brandes (Konstanz) and Willems (Leiden).

How do you detect people at high risk of heart attacks and strokes? And how can we improve the treatment of atherosclerosis? These are the questions that keep LACDR researcher Marie Depuydt busy. She is investigating the immune cells that contribute to the worsening of atherosclerosis. ‘It's a challenging…

The World of the Fullo takes a detailed look at the fullers, craftsmen who dealt with high-quality garments, of Roman Italy. Analyzing the social and economic worlds in which the fullers lived and worked, it tells the story of their economic circumstances, the way they organized their workshops, the…

As far back as 1575, Leiden University researchers have been leaving their mark on the world.

Dr. Jessica Kiefte-de Jong and Dr. Thijs Bosker, both Assistant Professors at LUC, have been awarded by The Leiden University Fund (LUF).

Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…

The development of space resource activities is happening now. In the absence of a clear framework to govern these activities, there is a need to examine the concepts that are being discussed in order to ensure that they meet existing treaty obligations regarding on-orbit operations and space resource…

Turning the tables on the misconception that Ezra Pound knew little Greek, this volume looks at his work translating Greek tragedy and considers how influential this was for his later writing.

Lecture

PhD candidate Maia Casna was a guest on the new episode of the Wetenschappelijke Wezens podcast. In it, Maia discusses her research on urbanisation and respiratory diseases while uncovering the intricacies of studying the human past and bones.

PhD student Wen Yang discovered how certain cell receptors in E. coli bacteria signal 'smells'. With the use of ice-cold electron microscopy microbiologists from Leiden gain more insight into how bacteria respond to their environment. Publication in mBio.

This summer postdoctoral researcher Mónica Varela from the Institute of Biology Leiden was awarded a Veni grant from the Dutch Research Council (NWO). Six questions about her project and hopes for the future.

Research aims: Identification of key genes involved in programming the cellular architecture of A. niger & Genetic engineering of A. niger in order to improve its secretory capacities and rheological behavior under industrial fermentation conditions.

How do macrophages and neutrophils contribute to metastatic onset?

This functional genomics project aims at understanding the biology of the underlying mycelium differentiation and autolysis processes in much more detail.

What are key regulators of plant ageing that can reverse ageing in plants (rejuvenation), and how can we use this knowledge to improve crop plants?

Law and peace in the work of Hans Kelsen. A re-evaluation of Kelsen’s legal philosophy: legal pacifism as tacit meaning of his Pure Theory of Law

Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…

Our group is part of the Metabolomics and Analytics Centre where we accompany the data from its acquisition all the way to the publication of identified associations and biomarkers for a range of human diseases. The generated data of the metabolic measurements are assessed using an in-house quality…

The master's specialisation Health and Medical Psychology consists of three main parts: the mandatory and elective courses, a thesis and an internship.

At Leiden University, in both our biomedical and biological research, we use laboratory animals. Learn more about these specific areas of research and the goals we aim to achieve through these studies.

The ambition of the Metabolomics and Analytics Centre led by Thomas Hankemeier is to develop innovative analytical strategies for metabolomics-driven health monitoring and systems biology studies. Understanding the intricate balance between health, disease and adaptation to challenges relies on the…

An international team of researchers, involving members from the ERC Synergy project NEXUS 1492 based at the Leiden University, the Universities of Oklahoma, Copenhagen and York reveal challenges when studying ancient microbiomes in a recent issue of Scientific Reports.

Archaeologist Hayley Mickleburgh has already appeared in the Dutch papers a few times already due to her unusual work: the study of decomposing bodies. She studied at Leiden University, where she is now a researcher.

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

The ADAPTED (Alzheimer's Disease Apolipoprotein Pathology for Treatment Elucidation and Development) project is a major new initiative to investigate an area of Alzheimer's Disease (AD) research which has previously received little attention. The project aims to improve understanding of the function…

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

In the Drug Research theme, we primarily work with rodents. Rodents, such as mice, are one of the most common laboratory animals. These small mammals are easily housed and exhibit a rapid rate of reproduction.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Control of infectious diseases poses continuous challenges for human health.

Lecture, MAIR Seminar

Lecture, LUCIS What's New?! Series