The aim is to develop methods to assess environmental and occupational exposure to (individual) pesticides, to be applied in epidemiological studies investigating pesticide exposure and human health. Furthermore, we aim to investigate the potential association between exposure to pesticides and Parkinson’s…

Earlier this year, the public voted environmental scientist Paul Behrens Discoverer of the Year 2018. Behrens is an interdisciplinary scientist who wants to understand our impact on the planet. ‘Unfortunately, we are not doing enough. Huge changes are underway and we’re running out of time to avoid…

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax

George Floyd's death still leads to fierce protests against police violence and racism on a daily basis in the United States and abroad. We asked Paul Wouters how he experiences these developments and what this will mean for our faculty.

Students of the Bachelor Honours Class 'Strategies of Resilience' are exposed to a unique educational experience. Through philosophical insights and creative exercises, participants explore what it means to be resilient. ‘I really feel like it helps you develop as a person.’

How can zebrafish models be used to gain a better understanding of host-pathogen interaction mechanisms and to screen new drugs for infectious disease treatment?

Amerindian settlement patterns and early colonial cartography in Northern Hispaniola

How can Staphylococcus aureus bacteria subvert the host immune system?

TRANSAUTOPHAGY is a European COST action to promote multidisciplinary research on autophagy and translation of knowledge to applications.

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Female and male songbirds sing equally elaborate songs in some species, but in others, females do not sing like males or not at all. How did such pronounced differences in male and female communication evolve?

How can cell wall engineering approaches be used to improve streptomycetes for industry to make new antibiotics?

We aim to unravel the complex and intertwining regulatory systems that control development and antibiotic production in streptomycetes.

RARE-NL, a new collaboration between university hospitals, hopes to find treatments for rare diseases. Professor Teun van Gelder is representing the LUMC in the initiative.

We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.

When parking in reverse, your car skids off just a little, hitting the wall of the parking garage. On the car dashboard, a warning light immediately starts blinking. This technique from new cars can also be used for another purpose, namely in the treatment of Parkinson's disease patients.

Some conflicts involve many Muslims as foreign fighters; other conflicts attract only relatively few combatants from abroad. Isabele Duvesteyn and Bram Peeters

Alireza Mashaghi from the Leiden Academic Centre for Drug Research (LACDR) will use state-of-the-art technology to investigate proteins that play a role in muscular dystrophy. His goal is to provide new insights for designing novel therapeutic strategies in the future. To accomplish this, Mashaghi receives…

Starting as an MP during the Covid-19 pandemic and after the recent ‘role elsewhere’ debacle during the coalition talks for a new Dutch government, alumna Mariëlle is looking forward to making a real contribution in society.

Minister Grapperhaus wants to use intelligence services in the investigation of drug crime. There are many doubts about this wish in the intelligence world. Paul Abels, Professor by Special Appointment Governance of Intelligence and Security Services at the Institute of Security and Global Affairs (ISGA),…

In recent months, the Dutch Islamic Haga Lyceum has increasingly come under the suspicion. The school is suspected of spreading a state-threatening version of the Salafist doctrine. This information came from the Dutch Intelligence and Security Service (AIVD).

Hans Ulrich Scherer is Professor of Rheumatology, in particular Translational Rheumatology. He wants to build bridges between research and clinical practice and between departments and organisations at home and abroad. Scherer will give his inaugural lecture next Friday. ‘To make progress, we have to…

At the start of the COVID-19 pandemic, researchers from 15 departments at Leiden University Medical Center (LUMC) realised they could do more for patients if they joined forces. This is how the BEAT-COVID group has been able to rapidly gain knowledge about COVID-19, the role of the immune system and…

When mosquito eggs hatch in nutrient-rich water, the mosquitoes are larger and they can also fly further. That is the first conclusion of a study from by the Netherlands Centre for One Health (NCOH) by PhD-student Sam Boerlijst.

Fourteen bachelor’s and master’s students are representing Leiden University in this year’s International Genetically Engineered Machine competition (iGEM). Their plan: to create a kit that can be used to quickly identify infectious diseases in case of an outbreak.

Back in 2008, Jason Laffoon moved from Chicago to Leiden. He came to join the Faculty of Archaeology’s Caribbean research group as a PhD candidate. Now he is an assistant professor, bridging departments through his innovative research methods. ‘I focus both on the archaeology of the Americas, as well…

Target selectivity is an important aspect of any drug molecule, and certainly a parameter to be optimized. That is not trivial for a number of reasons. First of all hundreds of drug targets (receptors, enzymes, ion channels) exist, and no single lab in the world has assays for all of them.

Paul Wouters came to the Faculty of Science for a few months to help with organising day-to-day issues after the previous dean left. This has involved rather more than he expected. ‘I can now really understand why every faculty has its own dean.’

Ben de Jong and Paul Abels, both working for ISGA, discuss the Russian claim that espionage equipment was found in Dutch newspaper Algemeen Dagblad (AD). According to the Russians the equipment was found in one of the cars used by their diplomats in The Hague.

Patients with skin diseases such as eczema and psoriasis, sometimes spend a lifetime searching for the right medication. To help these patients faster and better, scientists across the country are joining forces. The Next Generation ImmunoDermatology (NGID) project, with LACDR professor Robert Rissmann…

A job thanks to COVID—something not many people can claim. But PhD candidate Vera Arntzen can. Over the past four years, she has mapped two crucial characteristics of SARS-CoV-2 infections. Thanks to her research, experts can now make well-informed decisions on matters like quarantine duration, which…

We aim to develop a microfluidic platform that can parallelize testing the performance and characteristics of pure, mixed and environmental bacteriophage samples.

Lecture

At the division of BioTherapeutics, Amanda Foks, Bram Slütter and Ilze Bot have obtained a €4 million research grant from the HORIZON 2022 EIC Pathfinder Challenge “Cardiogenomics”, entitled “B-specific: B-cell related gene and protein markers with prognostic and therapeutic value for CVD”.

Astronomical observations in Chile, research into native heritage or the treatment of eye diseases in Brazil - Leiden is researching a large number and a wide variety of different topics in Latin America and the Caribbean. Researchers and representatives from 20 countries met on 11 May in Leiden to…

A central and much debated topic in the study of language acquisition concerns the nature of the learning mechanisms that are required. Are the computational and learning mechanisms that guide learning about language structure special and specific to language or humans?

Sexual homicide is a rare phenomenon. Yet, sexual killing is widely reported on in the media. Even though academic research on sexual homicide is conducted abroad, in the Netherlands such research is virtually absent.

Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease progression and treatment response. A Systems Medicine approach, based on computational…

An e-coaching programme helps people with chronic kidney disease, particularly in areas that patients themselves want to work on. ‘A healthy lifestyle is important for patients with kidney disease: it can slow down the loss of kidney function and there will be fewer complications,’ Katja Cardol explains…

A vitamin D deficiency is often associated with smoggy English industrial cities during the Industrial Revolution, but research carried out on skeletons now suggests that the ‘English disease’ was also prevalent in rural areas of the Netherlands. Doctoral defence on 29 January.

During illness, the stiffness or viscosity of cells can change. Tom Evers demonstrated this by measuring such properties of human immune cells for the first time. ‘The stiffness of certain cells could be a way to make a diagnosis,’ Evers said. He defended his thesis on March 26th.

We present our plans on five work areas: Students, Inclusive Education, Staff, Research, and Accessible and Inclusive Learning and Working Environment. For each work area, we explain which topics are relevant and what policy measures we (plan to) take.

Detection of cerebral beta-amyloid (Abeta) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer's disease (AD). Bis-styrylbenzenes have been previously reported as potential Abeta imaging agents.

Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

The skin protects the body from unwanted influences from the environment as well as excessive water loss. The barrier function of the skin is located in the stratum corneum (SC).

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

How can zebrafish research help understanding human diseases?