In contemporary India, the regional state of West Bengal has often been perceived as somewhat of an aberration in the wider context of a rather chaotic democracy, as the Left Front (spearheaded by the Communist Party of India-Marxist, CPIM) demonstrated a rare instance of political stability, decisively…

Biosynthetic gene clusters (BGCs) for natural products are widespread in microbial genomes, and they are rapidly exchanged. This research assesses the factors that control the spread of BGCs and resistance genes in nature. This includes risk assessment for the spread of engineered DNA in nature.

Biophysicist Alireza Mashaghi and his collaborators are taking up the fight against muscular dystrophy: genetic disorders that cause muscle weakness. They want to inhibit the clumping of proteins that results in toxic aggregates. For this, the team receives 550,000 euros from Health Holland. The team…

Visualization of biomolecules in living cells by tagging with gold nanoparticles.

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

For medical research, researchers often recreate tissue in the lab. Organ-on-a-chip technology emulates organs, right down to the blood that flows through them, thus creating a realistic test model for drugs or research into disease processes. Researchers from the LUMC are coordinating an NWO Gravitation…

With the powerful electron microscopes at NeCEN we study abnormalities in cells of blood vessels in cardiovascular disease, the interaction between pathogens and hosts in infectious diseases, molecular processes that cause cancer and the interaction between drugs and target proteins. Drug development…

The book ‘The Best of Times, The Worst of Times: Futures from the Frontiers of Climate Science’ by Paul Behrens has been launched in the US, a year after its original release in Europe. In his book, Behrens describes both hopeful and pessimistic scenarios for our planet.

Organs and tissues grown in the lab may in the future be able to cure people with organ failures. Micha Drukker, professor of Stem Cells, Developmental Biology and Technology for Innovative Drug Research, is convinced that the use of stem cells will make this possible. He will deliver his inaugural…

Paul Christiaan Flu, originally from Surinam, was a brilliant tropical doctor, who in 1938 rose to the position of Rector Magnificus of Leiden University. The war years brought his lightning career to an abrupt end: his son was murdered and he himself was imprisoned in a concentration camp. A sad family…

Two bacterial species team up inside the plant root system to rescue their host from fungal infection. This was discovered by a team of microbiologists and bioinformaticians from the Netherlands Institute of Ecology, Wageningen University, and the Institute of Biology Leiden. They also identified the…

Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.

Cardiovascular syndromes are the major cause of death in Western societies.

What are key regulators of plant ageing that can reverse ageing in plants (rejuvenation), and how can we use this knowledge to improve crop plants?

In July, 2018, the Institute of Biology Leiden hosted the 11th conference of the Zebrafish Disease Models Society (ZDMS), an international association dedicated to the advancement of basic and clinical research using zebrafish disease models. More than 350 researchers from all over the world gathered…

The Faculty of Science grants two C.J. Kok awards each year: the C.J. Kok Public Award, also known as the award for the ‘Discoverer of the Year’, and the C.J. Kok Jury Award, the award for the best PhD thesis from the past year.

A combination of two potential drugs gives hope of a 'super blockage' of an over-active immune system, Leiden researchers report in Nature. The breakthrough came from the crystallisation of a membrane protein.

Although coeliac disease, an autoimmune disorder that makes you gluten intolerant, occurs in 1% of the population, its diagnosis is often delayed or completely overlooked. To prevent health problems, this must change. That is what Professor of Paediatrics Luisa Mearin said at her inaugural lecture on…

The Cleveringa chair was installed by Leiden University in memory of Professor Rudolph Pabus Cleveringa and the courage he demonstrated in November 1940 during the German occupation . It also commemorates the liberation of the Netherlands in 1945.

Professor by Special Appointment of Clinical Neuropharmacology Geert Jan Groeneveld will deliver his inaugural lecture entitled ‘The importance of the biomarker’ on 11 March 2022. According to him, new genetic knowledge will revolutionise drug research.

Meniere’s disease, a disorder of the inner ear, was first described back in 1861, but there’s still no good test or treatment for it. Tjasse Bruintjes, Professor by Special Appointment of Ear, Nose and Throat Surgery, wants more attention for this mysterious disease. And he wants to tell his fellow…

Leiden Scientists are getting prepared to tackle future epidemics. A group of scientists led by Dr. Alireza Mashaghi has used innovative engineering approaches to make the first “Lassa Hemorrhagic Syndrome on-a-Chip”. World Health Organization has listed Lassa fever among diseases that pose the greatest…

How can the Netherlands be better prepared for infectious diseases transmitted by mosquitoes. The Dutch Research Council (NWO) has awarded almost 9 million euros for this research. Maarten Schrama from the Institute of Environmental Sciences CML coordinates the input of Leiden University within the…

By measuring proteins in tears, ophthalmologists can more easily diagnose dry eyes (Dry Eye Disease). Peter Raus, a Belgian ophthalmologist and PhD student at the Institute of Biology Leiden, developed a new method for protein determination in tear fluid. The technique is also promising for the early…

New funding allows IBL-researcher Herman Spaink to purchase a measurement device for more studies on human diseases such as cancer and tuberculosis using zebrafish as the model system.

Ontwikkeling van resistentie tegen antibiotica kan optreden als patiënten onnodig of te lang met antibiotica behandeld worden. Diagnostiek waarmee snel een bacteriële infectie vastgesteld kan worden, of de response op antibiotica bepaald kan worden, zijn daarom belangrijk om therapie te optimaliseren…

Professor P.F. (Paul) Wouters has been appointed dean of the Faculty of Social and Behavioural Sciences with effect from 1 January 2019. Wouters has been appointed for a period of three years and succeeds Professor Hanna Swaab, whose second term of office as dean expires this year. Swaab will remain…

Exceptional collaboration between physicians is needed to better understand and treat autoimmune diseases that cause inflammation in various organ systems.

Leiden University 2016 thesis awards were awarded to Kaspar Pucek (History), Mariska Meijer (Bio Medical Sciences) and Paul Kozowyk (Archaeology).

In August it was announced that Jeff Fynn-Paul was named co-recipient of a 15,000 EUR grant given by the Spanish Ministerio de Economía y Competitividad (MINECO).

Constant Hijzen, assistant professor at the Institute of Security and Global Affairs (ISGA), spoke about the Law on intelligence and security services in the NRC. In the column ‘Twistgesprek’ (dispute) of the NRC Hijzen has a written conversation with the director of Bits for Freedom, Hans de Zwart,…

Promotor: Prof.dr. J. Kuiper, Co-Promotor: S.C.A. de Jager

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

Sarah de Rijcke and Paul Wouters (CWTS) are partners in a new European consortium funded by the Swedisch Riksbankens Jubileumsfond: Knowledge in science and policy.

On 1 September 2017, Prof. dr. Paul H.A.M. Abels (60) will start as professor by special appointment of Governance of Intelligence and Security Services at Leiden University. This chair is placed at the Institute for Security and Global Affairs (ISGA).

Patients with the same illness often receive the same treatment, even if the cause of the illness is different for each person. This represents a new step towards ultimately being able to offer every patient more personalised treatment.

They can play a role in metabolic disorders and can break down tough plant fibers: β-glycosidases are enzymes that play many roles in nature. Fredj Ben Bdira changed these enzymes in order to enhance the production of clean energy and to improve the treatment of patients with metabolic diseases.

Exploiting metabolic vulnerabilities to identify anticancer compounds in zebrafish synthetic lethality screens.

Do humans and zebra finches share cognitive mechanisms that are important for speech perception?

How does FoxP1 affect auditory perception on a behavioural and genomic level?

Most of us know that Venice, Genoa, and Florence were major Mediterranean powers during the Renaissance. But did you know that in terms of trade and sea power, Barcelona was probably more powerful than two of these three?

Following the murder of two Dutch people - of which Iran is suspected - Trouw investigates how usual these practices are. Paul Abels, Professor of Intelligence Studies and Ben de Jong, Researcher, both working at the Institute of Security and Global Affairs (ISGA), will address the subject.

In the Netherlands, 1.55 million people suffer from cardiovascular diseases. Yet, acute cardiovascular events, such as a heart attack or stroke, often occur unexpectedly. That is because many people do not know they are at risk for such an event. Immunological researcher Amanda Foks and her colleagues…

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.