Target selectivity is an important aspect of any drug molecule, and certainly a parameter to be optimized. That is not trivial for a number of reasons. First of all hundreds of drug targets (receptors, enzymes, ion channels) exist, and no single lab in the world has assays for all of them.

Astronomical observations in Chile, research into native heritage or the treatment of eye diseases in Brazil - Leiden is researching a large number and a wide variety of different topics in Latin America and the Caribbean. Researchers and representatives from 20 countries met on 11 May in Leiden to…

Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease progression and treatment response. A Systems Medicine approach, based on computational…

An e-coaching programme helps people with chronic kidney disease, particularly in areas that patients themselves want to work on. ‘A healthy lifestyle is important for patients with kidney disease: it can slow down the loss of kidney function and there will be fewer complications,’ Katja Cardol explains…

Sexual homicide is a rare phenomenon. Yet, sexual killing is widely reported on in the media. Even though academic research on sexual homicide is conducted abroad, in the Netherlands such research is virtually absent.

A vitamin D deficiency is often associated with smoggy English industrial cities during the Industrial Revolution, but research carried out on skeletons now suggests that the ‘English disease’ was also prevalent in rural areas of the Netherlands. Doctoral defence on 29 January.

During illness, the stiffness or viscosity of cells can change. Tom Evers demonstrated this by measuring such properties of human immune cells for the first time. ‘The stiffness of certain cells could be a way to make a diagnosis,’ Evers said. He defended his thesis on March 26th.

Detection of cerebral beta-amyloid (Abeta) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer's disease (AD). Bis-styrylbenzenes have been previously reported as potential Abeta imaging agents.

Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

The skin protects the body from unwanted influences from the environment as well as excessive water loss. The barrier function of the skin is located in the stratum corneum (SC).

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

Do large deletions represent a risk during CRISP/CAS9-mediated genome editing in plants?

The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…

How can zebrafish research help understanding human diseases?

We present our plans on five work areas: Students, Inclusive Education, Staff, Research, and Accessible and Inclusive Learning and Working Environment. For each work area, we explain which topics are relevant and what policy measures we (plan to) take.

What is the role of auxin in the initiation and process of somatic embryogenesis?

In the MS Cognitietour, psychologists and neuroscientists from Leiden University discuss the latest scientific knowledge with MS patients and their loved ones. This leads to insights: 'One lady told how much stress she felt from all those caregivers around her bed.'

We aim to understand ion homeostasis in the model eukaryote S. cerevisiae.

Decent work involves opportunities for work that delivers a fair income, care for occupational health and safety, freedom for people to organize and equality of opportunity and treatment for all women and men. The Labour Law department at Leiden University conducts research and provides education on…

How is inflammation in tuberculosis controlled by interplay between autophagy and inflammasome signalling?

The word ¨pyroptosis¨ can be understood as ¨fiery falling¨, which describes the bursting of pro-inflammatory signals from the dying cell. Our observations indicate that pyroptosis also ¨spreads like wildfire¨ and once a cell dies via pyroptotic cell death, neighbouring cells are more prone to die as…

In Indigenous Ancestors and Healing Landscapes Jana Pešoutová presents new interpretations of current healing practices in Cuba and the Dominican Republic juxtaposed against the European colonization of the Caribbean after 1492.

Bringing Dominican indigenous collections back to the community

This research combines archaeological, archaeometric and ethnohistorical research to study the organisation of settlement space and residence rules among the Taino Indians during the Late Ceramic Age (AD 1000-1492).

Drones are proving to be a good means of mapping man-made changes in the landscape. Geophysicist Till Sonneman and his colleagues (archaeology) are experimenting with drones in inaccessible areas of the Caribbean.

The structure of bacterial cells provides crucial clues about their interaction with their host. What are the key structural features of a bacterial cell that determine pathogenicity? What roles do these structures play in the life cycle, and how do they change during the infection process?

A research into homicide.

Effective host defence against tuberculosis bacteria depends on a properly balanced level of inflammation. The Inflammafish project uses zebrafish larvae to study how autophagy controls this inflammation and vice versa.

Heart failure is a major health care problem with high mortality.

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

This study aims to answer two main research questions: (1) What are the main predictors of work ability in employees with migraine? (2) Can we optimise work ability in employees with migraine using a web-based intervention focused on these relevant predictors?

The Grotius Centre Working Paper Series is an occasional series through which researchers in the Grotius Centre can publish the unedited versions of manuscripts that have been accepted for publication by journals and books.

If you’re experiencing too much work pressure, talk about it to your colleagues and your manager. This is the only way we can jointly work towards a solution. How do you raise the issue of work pressure? And what can you do to prevent work pressure from getting out of hand?

Can we enhance the capacity of host immune cells to kill mycobacteria via production of reactive nitrogen species?

The document below contains the faculty D&I work plan drawn up for Leiden Law School. This work plan is linked to the University work plan of the D&I Expertise Office.

Together with patient representatives, clinician-researchers from Radboucumc (Internal Medicine) Amsterdam UMC and researchers from Leiden University (Andrea Evers and Henriët van Middendorp) have received the Medical Inspirator Prize 2019 of The Netherlands Organisation for Health Research and Development…

Many students want to find themselves a job during their studies, to help cover their expenses for example, or they might want to stay and work in the Netherlands after graduating. While there are certainly possibilities in both these areas, you’ll need to bear in mind that there are also restrictio…

Promotores: Prof. Dr. Th.J.C. van Berkel, Prof. Dr. M. van Eck

Are you interested in one of our vacancies? To get to know each other well, we follow a number of steps in the application process.

As a new vision on food production, the feasibility study on LED light to grow crops with the biological- and chemical evaluation of final products.

Biosynthetic gene clusters (BGCs) for natural products are widespread in microbial genomes, and they are rapidly exchanged. This research assesses the factors that control the spread of BGCs and resistance genes in nature. This includes risk assessment for the spread of engineered DNA in nature.