Leiden heritage expert Sjoerd van der Linde is carrying out research on the heritage of the Caribbean region. This research forms part of the international Nexus 1492 project on the consequences of colonisation for the Americas. ‘We first have to find out what the local population wants.'

Organs and tissues grown in the lab may in the future be able to cure people with organ failures. Micha Drukker, professor of Stem Cells, Developmental Biology and Technology for Innovative Drug Research, is convinced that the use of stem cells will make this possible. He will deliver his inaugural…

Two bacterial species team up inside the plant root system to rescue their host from fungal infection. This was discovered by a team of microbiologists and bioinformaticians from the Netherlands Institute of Ecology, Wageningen University, and the Institute of Biology Leiden. They also identified the…

Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.

Cardiovascular syndromes are the major cause of death in Western societies.

In July, 2018, the Institute of Biology Leiden hosted the 11th conference of the Zebrafish Disease Models Society (ZDMS), an international association dedicated to the advancement of basic and clinical research using zebrafish disease models. More than 350 researchers from all over the world gathered…

A combination of two potential drugs gives hope of a 'super blockage' of an over-active immune system, Leiden researchers report in Nature. The breakthrough came from the crystallisation of a membrane protein.

Although coeliac disease, an autoimmune disorder that makes you gluten intolerant, occurs in 1% of the population, its diagnosis is often delayed or completely overlooked. To prevent health problems, this must change. That is what Professor of Paediatrics Luisa Mearin said at her inaugural lecture on…

Professor by Special Appointment of Clinical Neuropharmacology Geert Jan Groeneveld will deliver his inaugural lecture entitled ‘The importance of the biomarker’ on 11 March 2022. According to him, new genetic knowledge will revolutionise drug research.

Meniere’s disease, a disorder of the inner ear, was first described back in 1861, but there’s still no good test or treatment for it. Tjasse Bruintjes, Professor by Special Appointment of Ear, Nose and Throat Surgery, wants more attention for this mysterious disease. And he wants to tell his fellow…

Leiden Scientists are getting prepared to tackle future epidemics. A group of scientists led by Dr. Alireza Mashaghi has used innovative engineering approaches to make the first “Lassa Hemorrhagic Syndrome on-a-Chip”. World Health Organization has listed Lassa fever among diseases that pose the greatest…

How can the Netherlands be better prepared for infectious diseases transmitted by mosquitoes. The Dutch Research Council (NWO) has awarded almost 9 million euros for this research. Maarten Schrama from the Institute of Environmental Sciences CML coordinates the input of Leiden University within the…

By measuring proteins in tears, ophthalmologists can more easily diagnose dry eyes (Dry Eye Disease). Peter Raus, a Belgian ophthalmologist and PhD student at the Institute of Biology Leiden, developed a new method for protein determination in tear fluid. The technique is also promising for the early…

New funding allows IBL-researcher Herman Spaink to purchase a measurement device for more studies on human diseases such as cancer and tuberculosis using zebrafish as the model system.

Aceruloplasminemia is a very rare, genetic disease accompagnied with iron accumulation that causes movement disorder and brain damage at early age.

Exceptional collaboration between physicians is needed to better understand and treat autoimmune diseases that cause inflammation in various organ systems.

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

Promotor: Prof.dr. J. Kuiper, Co-Promotor: S.C.A. de Jager

Patients with the same illness often receive the same treatment, even if the cause of the illness is different for each person. This represents a new step towards ultimately being able to offer every patient more personalised treatment.

They can play a role in metabolic disorders and can break down tough plant fibers: β-glycosidases are enzymes that play many roles in nature. Fredj Ben Bdira changed these enzymes in order to enhance the production of clean energy and to improve the treatment of patients with metabolic diseases.

On 3 April, Professor Syed Faisal Ahmed from the Leiden University Medical Center (LUMC) will give his inaugural lecture ‘Strength in Numbers’. He will emphasise the benefit of registries to rare disease research.

Exploiting metabolic vulnerabilities to identify anticancer compounds in zebrafish synthetic lethality screens.

In the Netherlands, 1.55 million people suffer from cardiovascular diseases. Yet, acute cardiovascular events, such as a heart attack or stroke, often occur unexpectedly. That is because many people do not know they are at risk for such an event. Immunological researcher Amanda Foks and her colleagues…

Do humans and zebra finches share cognitive mechanisms that are important for speech perception?

How does FoxP1 affect auditory perception on a behavioural and genomic level?

An international team of researchers, involving members from the ERC Synergy project NEXUS 1492 based at the Leiden University, the Universities of Oklahoma, Copenhagen and York reveal challenges when studying ancient microbiomes in a recent issue of Scientific Reports.

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

Due to the increasing resistance to certain antibiotics, the life-threatening condition sepsis is becoming harder to treat. For her PhD project, Leiden pharmacologist Feiyan Liu used mathematical modeling to find out how antibiotics can be used more effectively to cure sepsis.

This research project is an integral part of its mother-programme NEXUS1492 ERC Synergy Project directed by Prof. Corinne Hofman. Overarchingly, it aims at understanding and bridging from the archaeological perspective the late pre-colonial and early colonial history of the Southeastern Caribbean macroregion…

Alireza Mashaghi and his research team have created a new framework to understand shapes of proteins and DNA. With this framework, many diseases can be understood better.

Mapping of bacterial genomes to combat infectious diseases

A theoretical project on the insights gained by human (including infant), nonhuman animal and computational studies on artificial grammar learning; identifying the critical questions for future research by developing novel experimental and computational approaches to address these issues.

Every year, an NWO PhD in the Humanities grant is awarded to a prospective PhD candidate at the Faculty of Archaeology. This year, the grant went to Maia Casna, enabling her to study respiratory disease in the past. ‘My hypothesis is that the rapid formation of cities in the medieval Netherlands, must…

On 9 September, in the presence of King Willem Alexander, Secretary of State Sander Dekker presented the Spinoza Prize to four researchers, including two researchers from Leiden: archaeologist Corinne Hofman and physicist Dirk Bouwmeester. In the Nieuwe Kerk in The Hague, they unveiled their plans for…

Marlien van Mever delved into the analysis of tiny samples, cerebrospinal fluid from transgenic mouse models for example. She validated methods that can now be used to study brain diseases such as migraine and epilepsy. Van Mever will receive her PhD on 14 June.

Fake news about ‘patient zero’ and hyperbolic headlines warning about the ‘yellow peril.’ Leiden researchers have spotted fake news galore about coronavirus as well as racial stereotypes about the Chinese. How harmful is this?

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

Can thrips resistance in strawberry be explained based on secondary metabolite profiles and plant morphological traits?

How is vegetative development regulated in plants and how does this affect a plant’s life history strategy?

We aim to engineer streptomycetes to fully exploit their potential for natural product productions, by a rational design and evolution approach.

A thousand-year-old tooth has provided genetic evidence that the so-called

A new study published in Archaeometry describes the unexpected results obtained from analyses of five human teeth discovered in a ritual cache at an enslaved African plantation site on the island of Saba in the Caribbean.

The aim is to develop methods to assess environmental and occupational exposure to (individual) pesticides, to be applied in epidemiological studies investigating pesticide exposure and human health. Furthermore, we aim to investigate the potential association between exposure to pesticides and Parkinson’s…