A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

A History of Modern Political Thought in East Central Europe is a synthetic work, authored by an international team of researchers, covering twenty national cultures and 250 years. It goes beyond the conventional nation-centered narratives and presents a novel vision especially sensitive to the cross-cultural…

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

A History of Modern Political Thought in East Central Europe is a synthetic work, authored by an international team of researchers, covering twenty national cultures and 250 years. It goes beyond the conventional nation-centered narratives and presents a novel vision especially sensitive to the cross-cultural…

In the studies described in this study, we introduce a novel ex vivo human skin barrier repair model. To develop this, we removed the upper layer of the skin, the stratum corneum (SC) by a reproducible cyanoacrylate stripping technique.

This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…

Petra van der Bekerom, Joris van der Voet, and Johan Christensen, three assistant professors at Leiden University, conducted a large-scale survey experiment about whether citizens are more negative about failing service delivery than private organizations.

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.

Bachelor and Master students of all chemistry related studies are more than welcome to take part in our research activities. We have projects on design and synthesis of biologically relevant compounds within an ongoing research project. Supervision, following the apprentice/teacher model, is one of…

To argue that people can control the relative contributions of goal-driven and stimulus-driven processes to decision-making and action selection.

Source: Biosens Bioelectron, Volume 74, pp. 233-42 (2015)

In this article, the authors explore why there is substantial cross-national variation in the level of regulatory clarity surrounding cryptocurrencies

In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.

Corporeality, intimately bound to the notion of space, to the diffuse border that connects, entangles, and fuses an inside and an outside, is understood in this book as a space which puts the individual at stake as a war machine that, in its fight for a form of life, redefines political territories.

Detecting planets during their formation stages is crucial for understanding the history and diversity of fully developed planetary systems like our own. However, observing young planets directly is challenging because they are often deeply embedded within their host protoplanetary discs, rich in gas…

A History of Modern Political Thought in East Central Europe is a two-volume project, authored by an international team of researchers, and offering the first-ever synthetic overview of the history of modern political thought in East Central Europe.

This book contextualizes the use of terror as part of wider movements of political contention, demonstrating that terroristic innovation occurs as part of wider historical processes rather than in a vacuum.

Interactive exploration of large volumes of data is increasingly common, as data scientists attempt to extract interesting information from large opaque data sets. This scenario presents a difficult challenge for traditional database systems, as (1) nothing is known about the query workload in advance,…

Age of Rogues is a study of the frontier cultures of revolution that shaped the making of the modern Middle East. Rebels, revolutionaries, and racketeers played central roles in the violent process of imperial disintegration as it unfolded in the frontiers of the Ottoman, Habsburg, Romanov, and Qajar…

Haunting the future through poetry

Overview of the publications of the department of Environmental Biology (1972-2015)

Many important topics in computer science, such as the correctness of software, the efficiency of algorithms and the modeling of complicated systems, depend on sound theoretical underpinnings. In the Theory group, we study these fundamental building blocks and develop verification methods to prove system…

Many important topics in computer science, such as the correctness of software, the efficiency of algorithms and the modeling of complicated systems, depend on sound theoretical underpinnings. In the Theory group, we study these fundamental building blocks and develop verification methods to prove system…

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

CML report 192

Addressing Global Challenges through International Scientific Consortia

In his dissertation Gabriel Paiuk explores the variable ways in which what is heard is formed. To address this, he postulates a novel concept of sound image in a post-anthropocentric context in which both mind and material artefacts are instances across which the image occurs, rather than hosts on which…

The Faculty of Archaeology of Leiden University ran an excavation project in Northern Syria, at Tell Hammam al Turkman, some 80 km north of Raqqa. The Faculty of Archaeology and the Netherlands Organisation for Scientific Research N.W.O. finance the undertaking, which is directed by dr Diederik J.W.…

Leiden University regularly confers honorary doctorates, and presents awards and prizes.

Getting personal

Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

An overview of the research at the Biologics Formulation group

The Biomedical Microscale Analytics group is led by Dr. Rawi Ramautar. In present-day metabolomics, and bioanalysis in general, the analytical toolbox used encounters difficulties for the analysis of limited amounts of biological samples. As a result, a significant number of crucial biomedical/clinical…

Promotor: Prof.dr. S. Haring

How to understand the simultaneously dis- and reappearance of letters in contemporary culture, and how does this Neo-Epistolarity relate to media-technological change?

Bernard Bernards examines constraints on innovation by focusing on cognitive uncertainty as a personal state that may affect innovative work behavior.

To deliver a Virtual Sensor tool optimised to exploit the synergy between Sentinels 2 and 3 to allow the consistent retrieval of land surface parameters (Albedo, LAI, and LST); To extend the existing capabilities of land EO data assimilation tools to add capacity to handle data in the thermal domain…

How are digital risk-profiles developed and used in practice?

This paper written by Vydra and Kantorowicz answers the research question ‘What policy-relevant information does Twitter contain?’ as well as the research question ‘How does this information change between a period of normalcy and a period of crisis?’

As a new vision on food production, the feasibility study on LED light to grow crops with the biological- and chemical evaluation of final products.

Influenza CD8(+) T-cell epitopes are conserved amongst influenza strains and can be recognized by influenza-specific cytotoxic T-cells (CTLs), which can rapidly clear infected cells. An influenza peptide vaccine that elicits these CTLs would therefore be an alternative to current influenza vaccines,…

Can a proposed new radiofrequency approach to graphene biosensors lead to groundbreaking changes in genome mapping?

William Lippert investigates the effect of delegation to an agreement executor on success of conventional arms control agreements in Europe.

On 22 June, Anneke Koning defended the thesis 'Return to sender: a multi-method study of guardianship against transnational sexual exploitation of children'. The doctoral research was supervised by Joanne van der Leun, Masja van Meeteren and Johan van Wilsem.

Lecture, CHiLL series

Alexander Kros studies supramolecular systems in a biological environment. The unifying theme between the projects in my lab is specific molecular recognition, i.e. the intermolecular interaction between complementary molecules with high affinity and selectivity. Studying, imitating and dissecting processes…

The research of the Mathematical Institute is driven by the curiosity of its members and has many internal and external connections. It can be characterised as fundamental but with an open attitude towards applications.

An overview of awards and prizes granted to our staff and students in 2020, as well as special appointments at Leiden University and other institutions.

Hortus prefect Paul Keßler was a part of the delegation of Leiden researchers that traveled to Indonesia on a knowledge mission. In two weeks, he visited seven different universities and institutes and of course he also went to see three botanical gardens.