A new research line is the development of liquid biopsy fingerprints to predict early Alzheimer’s disease (AD) stage in human in readily accessible body fluids in human (in collaboration with: Dr. Geert-Jan Groeneveld, CHDR; Prof. Elga de Vries, Free University Medical Center; and others).

A main goal of MSBB research is to address the major bottle-necks in combatting viral diseases: the lack of experimental models that are representative of human pathology and are cost effective and versatile. Viral diseases such as those that cause viral hemorrhagic syndromes or severe acute respiratory…

Accelerating the diagnosis and personalising the management of inherited metabolic diseases.

Promotor: Prof.dr. J. Kuiper

How are the epidermal lipid pathways involved in health and disease.

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Chronic inflammatory skin diseases such as psoriasis and atopic dermatitis affect both the physical and psychological well-being of millions of patients, leading to persistent symptoms like itchiness and sleeplessness. These conditions often result in decreased productivity and quality of life overall,…

In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.

The overall objective of this project is to identify novel drug candidates that are capable of slowing down the progression of neurodegeneration in the subset of Parkinson’s disease (PD) patients with overt mitochondrial dysfunction. Multimodal phenotypic characterisation of cohorts of monogenic PD…

Timo Slootweg, associate professor at he department Philosophy of Law, published a chapter about Paul Scholten in

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

Leiden University researchers and their collaborators report the development of new research frameworks that use day-to-day smartphone behavior gathered from a large sample of healthy people to help understand aging, and how aging alters with epilepsy and stroke. These reports occupy two back-to-back…

The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

To make the right clinical decisions or develop effective diagnostic tests and treatments, it is important to understand the underlying mechanisms of a condition or behavior.

How to identify patients at risk of developing devastating, metastatic disease and facilitate the development of personalised treatment for prostate cancer patients?

We know this, but we don’t act on it: eat healthily, move more, address our stress levels and sleep well. Internist and Professor of Diabetology Hanno Pijl is fascinated by the effect that a healthy lifestyle can have on health. He researches how this lifestyle is achievable and satisfying, for patients…

Promotor: H.J.M. de Groot, Co-Promotor: A. Alia

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof. dr. A.H. Meijer

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

The goal of our research is to analyze Natorp’s redefinition of the distinction between intuitions and concepts in relation to his conception of the method of philosophy. We will exhibit the connection between the way in which Natorp redefines the Kantian dichotomy and his conception of the method of…

The following dissertation reconstructs Paul Natorp's philosophical psychology. It argues that psychology's main object is the lived experience of concrete subjects, understood as a transcendental structure of logical-reflexive conditions for the recognition, appropriation, and evaluation of objective…

Some conflicts involve many Muslims as foreign fighters; other conflicts attract only relatively few combatants from abroad. Isabele Duvesteyn and Bram Peeters

Health workers have always sought ways to fight disease in vulnerable groups in the population. It is now clear that such research also benefits more prosperous countries. African worm infections and innovative thermometers have shown Leiden researchers how to fight diseases of affluence and keep health…

We aim to gain a better understanding of the natural disease progression of ALS in order to improve clinical trial design and analysis and to support drug discovery and clinical development of new drugs.

A research into homicide.

This project is part of the Next Generation ImmunoDermatology (NGID) consortium, which focuses on the comprehensive phenotyping of six different immune-mediated inflammatory skin conditions. A common factor contributing to these diseases is a dysfunctional skin barrier. The skin barrier function is…

Psychologist Bernadet Klaassens initiated a large fMRI study on the effect of drugs on brain networks in aging and Alzheimer's disease. It generated a unique data set and insight into a new method to develop drugs for patients with Alzheimer's.

Peter Paul van Benthem is not only head of the ENT department at the LUMC but also chair of the Federation of Medical Specialists. ‘The value is in the mix.’

Which brain cell does what, when Parkinson's disease arises? It won't be long before this jigsaw is solved piece by piece. Ahmed Mahfouz, computational biologist, combines bio-knowledge from Leiden with algorithms from Delft and is getting closer to finding the key.

The aim of this project is to explore the use of statistical interaction models to quantify cross-omics and omics-drug interactions in large-scale clinical and experimental datasets

Prediction of human (CNS) target site concentrations in health and disease In the vision of Prof. de Lange we will only be able to predict human (central nervous system, CNS) target site concentrations and effects if we perform systematic, condition-dependent, integrative, and strictly quantitative…

Sexual homicide is a rare phenomenon. Yet, sexual killing is widely reported on in the media. Even though academic research on sexual homicide is conducted abroad, in the Netherlands such research is virtually absent.

Since 2014 church organ player Paul Houdijk has been working on his PhD project on the musical and aesthetic developments of the Dutch 19th-century church organ builder Michael Maarschalkerweerd.

Papers written on the occasion of the 30th anniversary of the Institute of Prehistory, Volume I.

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

PhD defence

PhD defence

PhD defence

It was with great sadness that on 17 May 2021 we learned of the death of our dear colleague Paul Valk. Paul died from the consequences of COVID-19, having been diagnosed with coronavirus over three weeks ago. Soon after this he was admitted to intensive care, where he was kept in an induced coma on…

Promotores: H.A. Udo De Haes, P.M. Brakefield

Currently, several successful vaccines are available. However, for pathogens with a highly variable genetic composition, and for which serum IgG antibodies are not a useful correlate of protection, effective vaccines are yet to be developed.

Paul Kozowyk has received one of the Archon PhD positions with his research proposal Sticking around: identification, performance and preservation of Palaeolithic adhesives.

Excavations on Saba took place between 1987 and 1992, and then in 2001 and 2002.

This subproject of 'From Homo Economicus to Political Animal' will be on ancient analogues for modern-day “ersatz economics”, the economics of the “man in the street”.

Decent work involves opportunities for work that delivers a fair income, care for occupational health and safety, freedom for people to organize and equality of opportunity and treatment for all women and men. The Labour Law department at Leiden University conducts research and provides education on…

We welcome Paul Sharp as The Hague Journal of Diplomacy's first Honorary Editor.

Since 1 February 2016, Paul van Trigt is postdoctoral researcher in the project Rethinking Disability: the Impact of the International Year of Disabled Persons (1981) in Global Perspective at the Institute for History.