Arteriosclerosis bears great similarities to autoimmune diseases. Researchers from Leiden University show this in a new study they published in the renowned scientific journal Nature Cardiovascular Research. 'This discovery suggests that treatment methods for autoimmune diseases might also be effective…

Researchers at Leiden University have made a breakthrough in the study of the hereditary Pompe disease. Together with colleagues in York, they have developed a molecule that binds to the enzyme that is key to the progress of the disease. The findings have been published in ACS Central Science.

Alzheimer’s disease and cancer are two examples of diseases that are related to malfunctioning cellular patterns. The examination of cell tissue, however, takes a lot of time and generates a lot of data. To make the analysis of data easier, Antonios Somarakis of the Data Science Research Programme (DSRP)…

In addition to cholesterol and high blood pressure as risk factors for atherosclerosis, we may need to address our own immune system to prevent a heart attack or stroke. Marie Depuydt revealed which cells exactly reside in the atherosclerotic plaque that narrows an artery. The presence of a diverse…

Scientific research at the molecular level on a collection of medieval skeletons from Norton Priory in Cheshire, United Kingdom, could help rewrite history after revealing they were affected by an unusual ancient form of the bone disorder, Paget’s disease. Osteoarchaeologist Carla Burrell, attached…

Can we bring novel treatment options to the clinic for UM patients with liver metastases?

Is it possible to diagnose diseases using molecular switches? The new international consortium LogicLab will address this question. Leiden chemist Sylvestre Bonnet and Leiden pharmacologist Thomas Hankemeier are involved in the project. LogicLab will run for four years and will receive over 3.5 million…

We use zebrafish as a model organism to study human development and disease as well as animal welfare and environmental impact.

In April, the X-omics initiative was granted 17 million euros from the Dutch Organization for Scientific Research. The subsidy is part of the National Roadmap for large-scale scientific infrastructure, intended to build or renew large-scale research facilities. What new insights will this investment…

In order to better understand the course of Alzheimer’s disease, Frédérique Kok believes that a strategic and structured approach is needed: the Mastermind research approach. With her LUF grant, Kok wants to generate high-quality data to build a mathematical model that can recognize the onset of the…

‘If we don’t start talking about this, who else will?’ This is what Arjan Lankester, paediatrician/immunologist at the Leiden University Medical Center (LUMC) and Professor of Paediatrics, thought when it seemed that various extremely effective gene therapies for rare diseases would no longer be available…

Scientific Director of the Leiden Academic Centre for Drug Research (LACDR) Hubertus Irth: ‘We test substances and look for new concepts for treating disease.’

Biophysicist Alireza Mashaghi and his collaborators are taking up the fight against muscular dystrophy: genetic disorders that cause muscle weakness. They want to inhibit the clumping of proteins that results in toxic aggregates. For this, the team receives 550,000 euros from Health Holland. The team…

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

Visualization of biomolecules in living cells by tagging with gold nanoparticles.

For medical research, researchers often recreate tissue in the lab. Organ-on-a-chip technology emulates organs, right down to the blood that flows through them, thus creating a realistic test model for drugs or research into disease processes. Researchers from the LUMC are coordinating an NWO Gravitation…

With the powerful electron microscopes at NeCEN we study abnormalities in cells of blood vessels in cardiovascular disease, the interaction between pathogens and hosts in infectious diseases, molecular processes that cause cancer and the interaction between drugs and target proteins. Drug development…

In the week of 14 to 18 January the Lorentz workshop 'Intersecting Worlds. The Interplay of Cultures and Technology' took place at the Lorentz Center in Leiden. Attracting many scholars from across the world, the workshop explored the transformations and responses of indigenous societies around the…

One and half years ago, Lewis Borck exchanged the arid and hot Southwest of the USA for the Netherlands. While an expert in Ancestral Pueblo and Hohokam archaeology, he switched to the Caribbean as a researcher in the NEXUS 1492 project. “Theories and methods brought me in first.”

Organs and tissues grown in the lab may in the future be able to cure people with organ failures. Micha Drukker, professor of Stem Cells, Developmental Biology and Technology for Innovative Drug Research, is convinced that the use of stem cells will make this possible. He will deliver his inaugural…

Two bacterial species team up inside the plant root system to rescue their host from fungal infection. This was discovered by a team of microbiologists and bioinformaticians from the Netherlands Institute of Ecology, Wageningen University, and the Institute of Biology Leiden. They also identified the…

Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.

Cardiovascular syndromes are the major cause of death in Western societies.

In July, 2018, the Institute of Biology Leiden hosted the 11th conference of the Zebrafish Disease Models Society (ZDMS), an international association dedicated to the advancement of basic and clinical research using zebrafish disease models. More than 350 researchers from all over the world gathered…

A combination of two potential drugs gives hope of a 'super blockage' of an over-active immune system, Leiden researchers report in Nature. The breakthrough came from the crystallisation of a membrane protein.

A mere day after setting foot ashore in the Bahamas on October 13th 1492, Christopher Columbus notes the broad foreheads of the inhabitants of the Americas. These permanently altered cranial shapes are deliberately created through the application of pressure to the head of the infant in the first years…

Although coeliac disease, an autoimmune disorder that makes you gluten intolerant, occurs in 1% of the population, its diagnosis is often delayed or completely overlooked. To prevent health problems, this must change. That is what Professor of Paediatrics Luisa Mearin said at her inaugural lecture on…

Historical figures such as Columbus have returned to the centre of public debate. Much remains to be discovered about his legacy and current impact on our society. A new study shows the ecological footprint that the arrival of Europeans left in the Caribbean islands.

Professor by Special Appointment of Clinical Neuropharmacology Geert Jan Groeneveld will deliver his inaugural lecture entitled ‘The importance of the biomarker’ on 11 March 2022. According to him, new genetic knowledge will revolutionise drug research.

Meniere’s disease, a disorder of the inner ear, was first described back in 1861, but there’s still no good test or treatment for it. Tjasse Bruintjes, Professor by Special Appointment of Ear, Nose and Throat Surgery, wants more attention for this mysterious disease. And he wants to tell his fellow…

Leiden Scientists are getting prepared to tackle future epidemics. A group of scientists led by Dr. Alireza Mashaghi has used innovative engineering approaches to make the first “Lassa Hemorrhagic Syndrome on-a-Chip”. World Health Organization has listed Lassa fever among diseases that pose the greatest…

On Wednesday January 25, Hayley Mickleburgh was hosted by the radio show de Kennis van Nu (NPO radio 1). Here she told about her work on a body farm in Texas. She investigates the decomposition processes of human remains.

How can the Netherlands be better prepared for infectious diseases transmitted by mosquitoes. The Dutch Research Council (NWO) has awarded almost 9 million euros for this research. Maarten Schrama from the Institute of Environmental Sciences CML coordinates the input of Leiden University within the…

By measuring proteins in tears, ophthalmologists can more easily diagnose dry eyes (Dry Eye Disease). Peter Raus, a Belgian ophthalmologist and PhD student at the Institute of Biology Leiden, developed a new method for protein determination in tear fluid. The technique is also promising for the early…

New funding allows IBL-researcher Herman Spaink to purchase a measurement device for more studies on human diseases such as cancer and tuberculosis using zebrafish as the model system.

Aceruloplasminemia is a very rare, genetic disease accompagnied with iron accumulation that causes movement disorder and brain damage at early age.

Exceptional collaboration between physicians is needed to better understand and treat autoimmune diseases that cause inflammation in various organ systems.

On Thursday January 19, 2017, Hayley Mickleburgh was invited to speak at the Dutch talkshow RTL Late Night. Here she talked about her research on so called 'body farms', where the decomposition of bodies is being investigated.

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

Promotor: Prof.dr. J. Kuiper, Co-Promotor: S.C.A. de Jager

Patients with the same illness often receive the same treatment, even if the cause of the illness is different for each person. This represents a new step towards ultimately being able to offer every patient more personalised treatment.

They can play a role in metabolic disorders and can break down tough plant fibers: β-glycosidases are enzymes that play many roles in nature. Fredj Ben Bdira changed these enzymes in order to enhance the production of clean energy and to improve the treatment of patients with metabolic diseases.

Exploiting metabolic vulnerabilities to identify anticancer compounds in zebrafish synthetic lethality screens.

In the Netherlands, 1.55 million people suffer from cardiovascular diseases. Yet, acute cardiovascular events, such as a heart attack or stroke, often occur unexpectedly. That is because many people do not know they are at risk for such an event. Immunological researcher Amanda Foks and her colleagues…

Do humans and zebra finches share cognitive mechanisms that are important for speech perception?

How does FoxP1 affect auditory perception on a behavioural and genomic level?

On 26 and 27 September 2016, the Faculty of Archaeology of Leiden University hosted the closing symposium of the HERA-CARIB project “Caribbean Connections: Cultural encounters in a New World setting”.