Target selectivity is an important aspect of any drug molecule, and certainly a parameter to be optimized. That is not trivial for a number of reasons. First of all hundreds of drug targets (receptors, enzymes, ion channels) exist, and no single lab in the world has assays for all of them.

The precolonial inhabitants of the Caribbean islands communicated, travelled, and exchanged objects and ideas along an expansive inter-island network. New methods of computer modeling shed light on these networks. Emma Slayton is set to discuss her work on this topic at her Defense on the 12th of Se…

Drones are proving to be a good means of mapping man-made changes in the landscape. Geophysicist Till Sonneman and his colleagues (archaeology) are experimenting with drones in inaccessible areas of the Caribbean.

Overkleeft

the production, use and exchange of bodily accoutrements through the lenses of the microscope

Amerindian intra- and inter-insular relationships and social organization in the pre-colonial Windward Islands.

Organisation of settlement space and residence rules among the Taino, the indigenous people of the Caribbean encountered by Columbus

The different kinds of cultural perspectives on health and disease of the participants are related to their knowledge, beliefs, values and practices manifested in various forms of lifestyle in Indonesia. The cultural diversity of the population is also related to differences in health behaviour.

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North, Middle and South America together constitute the single largest area in World Archaeology that is taught as a single focus. It is also the only major world area that saw societies develop from hunter-gatherers to early empires entirely independent from developments in Eurasia & Africa. It is,…

The research involves the application and combination of archaeological and archaeometrical methodologies. Petrographic analysis and isotopic provenance studies of raw materials and exotics, and the study of the distribution patterns of these materials are used to gain insight into the exchange of goods…

According to a new study by an international team of researchers from the Caribbean, Europe and North America, the Caribbean was settled by several successive population dispersals that originated on the American mainland.

Predictors of work functioning in persons with multiple sclerosis

More than fifty researchers are working together to describe the colonisation of the Americas from the Amerindian perspective. In November they will be meeting for the first time, in Leiden. How is Corinne Hofman, Leiden Professor of Archaeology managing the international megaproject Nexus 1492?

How does the endocannabinoid system in the zebrafish function at the molecular and phenotypic levels and how is it linked to the stress axis?

Unraveling the immune-suppressive actions of drugs like prednisone.

Can we build a biosensor to detect neuroblastoma markers in urine using the chemotaxis system in E. coli?

How can Europe lead the way in vaccine development that is fast and for all? To answer this pressing question, Professor of Vaccinology Meta Roestenberg is holding a panel session on 14 July at the EuroScience Open Forum in Leiden.

It is difficult to imagine a society other than a hierarchical nation-state. This is in part because we neglect alternative forms from the past, argues archaeologist Lewis Borck in the Journal of Contemporary Archaeology.

Researchers from Leiden University will develop a new approach to study the biomarkers of Alzeimer’s disease. This approach focusses on the molecular messengers of the cells. The project, led by Thomas Hankemeier and coordinated by Yuliya Shakalisava (Leiden Academic Centre for Drug Research, LACDR),…

Researchers from the Institute of Biology Leiden have discovered how good intestinal bacteria regulate our innate immune system. This surprising discovery could make it possible to treat diseases related to inflammation, such as diabetes and colitis, with a cocktail of good bacteria. Publication in…

Corinne Hofman (Professor in Caribbean Archaeology) has been awarded 15 million euro by the EU for her archaeological research on the colonisation of the Americas. She will lead the ‘NEXUS 1492’ project together with colleagues Davies (VU), Brandes (Konstanz) and Willems (Leiden).

The research connected to this topic is related to Work and health.

A novel in vivo model system for studies on glucocorticoid resistance

The changes that humans are making to the landscape are beneficial for mosquitoes that spread diseases such as Zika, chikungunya and dengue. This is what biologist Maarten Schrama and his colleagues write in the journal Nature Scientific Reports. ‘If we know in which living environments mosquitoes thrive…

Arteriosclerosis bears great similarities to autoimmune diseases. Researchers from Leiden University show this in a new study they published in the renowned scientific journal Nature Cardiovascular Research. 'This discovery suggests that treatment methods for autoimmune diseases might also be effective…

Researchers at Leiden University have made a breakthrough in the study of the hereditary Pompe disease. Together with colleagues in York, they have developed a molecule that binds to the enzyme that is key to the progress of the disease. The findings have been published in ACS Central Science.

Alzheimer’s disease and cancer are two examples of diseases that are related to malfunctioning cellular patterns. The examination of cell tissue, however, takes a lot of time and generates a lot of data. To make the analysis of data easier, Antonios Somarakis of the Data Science Research Programme (DSRP)…

In addition to cholesterol and high blood pressure as risk factors for atherosclerosis, we may need to address our own immune system to prevent a heart attack or stroke. Marie Depuydt revealed which cells exactly reside in the atherosclerotic plaque that narrows an artery. The presence of a diverse…

What are the capabilities or limitations of traveling between islands and how does this reflect seasonal variation? Is it possible to show higher levels of connectivity between islands based on generated pathways between several sites on two separate islands?

Can we bring novel treatment options to the clinic for UM patients with liver metastases?

Scientific research at the molecular level on a collection of medieval skeletons from Norton Priory in Cheshire, United Kingdom, could help rewrite history after revealing they were affected by an unusual ancient form of the bone disorder, Paget’s disease. Osteoarchaeologist Carla Burrell, attached…

Archaeologist Eduardo Herrera Malatesta reflects on the unfamiliarity with the pre-Columbian past that he encountered during fieldwork in the Montecristi province in the Dominican Republic.

Is it possible to diagnose diseases using molecular switches? The new international consortium LogicLab will address this question. Leiden chemist Sylvestre Bonnet and Leiden pharmacologist Thomas Hankemeier are involved in the project. LogicLab will run for four years and will receive over 3.5 million…

We use zebrafish as a model organism to study human development and disease as well as animal welfare and environmental impact.

In April, the X-omics initiative was granted 17 million euros from the Dutch Organization for Scientific Research. The subsidy is part of the National Roadmap for large-scale scientific infrastructure, intended to build or renew large-scale research facilities. What new insights will this investment…

In order to better understand the course of Alzheimer’s disease, Frédérique Kok believes that a strategic and structured approach is needed: the Mastermind research approach. With her LUF grant, Kok wants to generate high-quality data to build a mathematical model that can recognize the onset of the…

‘If we don’t start talking about this, who else will?’ This is what Arjan Lankester, paediatrician/immunologist at the Leiden University Medical Center (LUMC) and Professor of Paediatrics, thought when it seemed that various extremely effective gene therapies for rare diseases would no longer be available…

Scientific Director of the Leiden Academic Centre for Drug Research (LACDR) Hubertus Irth: ‘We test substances and look for new concepts for treating disease.’

Biophysicist Alireza Mashaghi and his collaborators are taking up the fight against muscular dystrophy: genetic disorders that cause muscle weakness. They want to inhibit the clumping of proteins that results in toxic aggregates. For this, the team receives 550,000 euros from Health Holland. The team…

Visualization of biomolecules in living cells by tagging with gold nanoparticles.

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

For medical research, researchers often recreate tissue in the lab. Organ-on-a-chip technology emulates organs, right down to the blood that flows through them, thus creating a realistic test model for drugs or research into disease processes. Researchers from the LUMC are coordinating an NWO Gravitation…

With the powerful electron microscopes at NeCEN we study abnormalities in cells of blood vessels in cardiovascular disease, the interaction between pathogens and hosts in infectious diseases, molecular processes that cause cancer and the interaction between drugs and target proteins. Drug development…