Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

Innovation plays an essential role in firms' competitiveness and long-term success. It varies from different types, ranging from run-of-the-mill innovation that brings incremental changes to existing technologies to radical innovation that breaks from existing trajectories.

Voltammetry plays a crucial role in modern scientific research by offering valuable insights into the electrochemical properties of materials, with wide-ranging applications in fields such as materials science, energy storage, corrosion studies, and sensor development.

This project aims to identify which aspects of exploring a novel environment produce beneficial effects on memory. The effects of novelty will be investigated across the lifespan, including children, adolescents and older adults.

The Leiden LIS Sectoral Income Inequality Dataset, assembled by Chen Wang, Stefan Thewissen and Olaf van Vliet (Version 1.1, March 2014), contains information on multiple indicators of earnings inequality and employment within 9 sectors and 12 subsectors, drawing upon micro data from Luxembourg Income…

The Delivery of Biotherapeutics research group is led by Prof. Matthias Barz and focusses on the synthesis and characterization of polypept(o)ids and their application in nanomedicine to improve existing therapies or enable novel diagnostic or therapeutic approaches.

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

While acknowledging prominent legal-philosophical debates, this project proposes a radically different approach to provide insights into the concept of the rule of law.

What performance criteria does a new technology have to fulfill in order to be added to the list of future energy options and what constraints exist in terms of broad market penetration?

In our lab, we investigate the physics and material properties of low-dimensional systems.

This research group, headed by Miranda van Eck, focusses on understanding the molecular mechanisms underlying cardiovascular and metabolic diseases. Cardiovascular disease constitutes a major health issue worldwide. Although significant knowledge has been obtained on the development of atherosclerotic…

These podcast episodes were written for the Green Office’s Spring Podcast competition and miniseries 'Beyond the Safe Space', on the theme: the Planetary Boundaries, which took place between the months of March-May 2023.

Tim Koopmans is one of the great minds in the history of Dutch and European legal scholarship. He taught law as a professor in Leiden and other universities, among which Ghent, Cambridge, Utrecht. He practiced it as a judge in the European Court of Justice and Advocate-General in the Dutch Supreme Court,…

This paper sheds light on how better monetary-fiscal coordination can be expected to play out across very different political-economic contexts.

This dissertation provides a novel perspective on the interaction between quantifier scope and ellipsis. It presents a detailed investigation of the scopal interaction between English negative indefinites, modals, and quantified phrases in ellipsis. One of the crucial observations is that a negative…

Petra van der Bekerom, Joris van der Voet, and Johan Christensen, three assistant professors at Leiden University, conducted a large-scale survey experiment about whether citizens are more negative about failing service delivery than private organizations.

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

How can pupils and students learn to get a grip on complex 'swamp situations'? Inaugural lecture in abbreviated form held by prof.dr.ir. Fred Janssen on the acceptance of the post of professor of science education at Leiden University on 19 June 2017.

States, we are told, have monopolized the legal right to wage war since the seventeenth century and this arrangement has provided some basic stability in international relations. But is this really true? This project challenges this classic account and opens the way for rethinking the contemporary laws…

Corporeality, intimately bound to the notion of space, to the diffuse border that connects, entangles, and fuses an inside and an outside, is understood in this book as a space which puts the individual at stake as a war machine that, in its fight for a form of life, redefines political territories.

Detecting planets during their formation stages is crucial for understanding the history and diversity of fully developed planetary systems like our own. However, observing young planets directly is challenging because they are often deeply embedded within their host protoplanetary discs, rich in gas…

A History of Modern Political Thought in East Central Europe is a two-volume project, authored by an international team of researchers, and offering the first-ever synthetic overview of the history of modern political thought in East Central Europe.

This book contextualizes the use of terror as part of wider movements of political contention, demonstrating that terroristic innovation occurs as part of wider historical processes rather than in a vacuum.

Interactive exploration of large volumes of data is increasingly common, as data scientists attempt to extract interesting information from large opaque data sets. This scenario presents a difficult challenge for traditional database systems, as (1) nothing is known about the query workload in advance,…

The research project SOG Pro (Structure of Government project) studies the changes in the structure and organization of central government in four parliamentary democracies: France, Germany, the Netherlands and the United Kingdom and aims to explain the changes within and across each country. Why are…

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

A History of Modern Political Thought in East Central Europe is a synthetic work, authored by an international team of researchers, covering twenty national cultures and 250 years. It goes beyond the conventional nation-centered narratives and presents a novel vision especially sensitive to the cross-cultural…

A History of Modern Political Thought in East Central Europe is a synthetic work, authored by an international team of researchers, covering twenty national cultures and 250 years. It goes beyond the conventional nation-centered narratives and presents a novel vision especially sensitive to the cross-cultural…

In the studies described in this study, we introduce a novel ex vivo human skin barrier repair model. To develop this, we removed the upper layer of the skin, the stratum corneum (SC) by a reproducible cyanoacrylate stripping technique.

To argue that people can control the relative contributions of goal-driven and stimulus-driven processes to decision-making and action selection.

This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…

In this article, the authors explore why there is substantial cross-national variation in the level of regulatory clarity surrounding cryptocurrencies

Source: Biosens Bioelectron, Volume 74, pp. 233-42 (2015)

In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.

Bachelor and Master students of all chemistry related studies are more than welcome to take part in our research activities. We have projects on design and synthesis of biologically relevant compounds within an ongoing research project. Supervision, following the apprentice/teacher model, is one of…

On 21 March 2019, James Welch defended his thesis 'The Grotius Sanction: Deus Ex Machina. The legal, ethical, and strategic use of drones in transnational armed conflict and counterterrorism'. The doctoral research was supervised by Prof. dr. P.B Cliteur.

Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.

On 21 November 2018, Lieke Kools defended her thesis 'Essays on wealth, health, and data collection'. The doctoral research was supervised by Prof. dr. K.P. Goudswaard en Prof. dr. C.L.J. Caminada.

Haunting the future through poetry

Age of Rogues is a study of the frontier cultures of revolution that shaped the making of the modern Middle East. Rebels, revolutionaries, and racketeers played central roles in the violent process of imperial disintegration as it unfolded in the frontiers of the Ottoman, Habsburg, Romanov, and Qajar…

Many important topics in computer science, such as the correctness of software, the efficiency of algorithms and the modeling of complicated systems, depend on sound theoretical underpinnings. In the Theory group, we study these fundamental building blocks and develop verification methods to prove system…

Many important topics in computer science, such as the correctness of software, the efficiency of algorithms and the modeling of complicated systems, depend on sound theoretical underpinnings. In the Theory group, we study these fundamental building blocks and develop verification methods to prove system…

CML report 192

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

Addressing Global Challenges through International Scientific Consortia

How to understand the simultaneously dis- and reappearance of letters in contemporary culture, and how does this Neo-Epistolarity relate to media-technological change?

In his dissertation Gabriel Paiuk explores the variable ways in which what is heard is formed. To address this, he postulates a novel concept of sound image in a post-anthropocentric context in which both mind and material artefacts are instances across which the image occurs, rather than hosts on which…

Promotor: Prof.dr. S. Haring

An overview of the research at the Biologics Formulation group