Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

In A History of Plague in Java, 1911–1942, Maurits Bastiaan Meerwijk demonstrates how the official response to the 1911 outbreak of plague in Malang led to one of the most invasive health interventions in Dutch colonial Indonesia.

The research connected to this topic is related to E-health.

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Although there has been an increase in the research into brain function and dysfunction in relation to stress and emotions, there are still many unanswered questions.

Macromolecular Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University, comprising the PIs Marcellus Ubbink, Remus Dame, Aimee Boyle, Lars Jeuken and Anne Wentink.

How are new drugs developed? This question is central to the Minor Modern Drug Discovery (MDD), which covers the entire trajectory from disease to drug molecule and vice versa. The various research groups involved offer a complementary and interdisciplinary perspective by connecting the diverse subjects…

This multidisciplinary minor provides students with knowledge on how and why humans became the way they are. The minor focuses on the evolution of the species Homo sapiens from other hominin lineages and animal ancestors, and on the various factors shaping this process. Not only is human evolution of…

If you wish to know exactly what is going on in a healthy or sick human body, and at various levels such as molecule, cell, tissue, organ, larger systems and a person as a whole? Do you wish to learn how to do research which contributes to diagnoses, treatment and prevention of diseases? Then the bachelor…

LUC graduates have an internationally-recognised Bachelors honours degree (BA/BSc) that qualifies them to apply for competitive programmes at top research universities. Over 90% of our alumni continue their studies into a master programme.

Diacylglycerol lipases (DAGLα and DAGLβ) are responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain and peripheral tissues. Selective DAGLβ inhibitors have been proposed as a potential treatment for inflammatory diseases with reduced potential for central…

The research at The Metabolomics & Analytics Centre is centered around developing innovating analytical methods to enable metabolomics-driven systems biology in personalized health strategies.

Biotherapeutics or biologics, such as proteins, peptides, and nucleic acids, comprise an increasing share of the pharmaceutical market, whilst offering new therapies for difficult-to-treat diseases. Most notable is their contribution to the vaccination efforts during the COVID-19 pandemic. In most cases,…

Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…

Natashe Lemos Dekker addresses the experiences of family members of people with dementia as they expressed their sense of gradually losing the person with dementia in the article 'Anticipatory Grief in Dementia: An Ethnographic Study of Loss and Connection' published in Culture, Medicine, and Psychi…

In the master's programme Biomedical Sciences you learn interdisciplinary approaches to address scientific and societal challenges in the field of (bio)medical sciences. The research in our programme relates to the maintenance of health and prevention of disease. You will acquire a skill set suitable…

In the master's programme Biomedical Sciences you learn interdisciplinary approaches to address scientific and societal challenges in the field of (bio)medical sciences. The research in our programme relates to the maintenance of health and prevention of disease. You will acquire a skill set suitable…

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

A Pointer investigation has found that more than 30 Dutch podcasts regularly spread misinformation. Assistant professor Michael Klos spoke to Pointer about preventing misinformation in the media: ‘Realistically, you’re never going to achieve 100% moderation.’

Four researchers from Leiden University have been awarded prestigious Vici grants the Dutch Research Council (NWO) has announced. The honoured applications are from researchers at the Faculty of Social and Behavioural Sciences, Leiden Observatory, the LUMC and the Faculty of Archaeology.

In this project, we will study the genetic and environmental drivers of woodiness and stem lignification at the level of plant‐to‐gene‐to‐molecule.

25 Years ago, the Center for Bio-Pharmaceutical Sciences was founded at Leiden University; one year later, in 1985, the education program of Bio-Pharmaceutical Sciences started. On Friday September 18th, this was celebrated with a Symposium, an anniversary booklet, and a grand party.

On 15 May, the ambassadors of 11 Latin American and Caribbean countries were shown the highlights of research at Leiden University Faculty of Science. Furthermore, Prince Carlos de Bourbon de Parme awarded prizes to two young academics who conduct research in Latin America.

The importance of a healthy lifestyle does not receive the attention it deserves, as the coronavirus pandemic made painfully clear. Twelve behavioural scientists, including Professor Behavioral Interventions in Population Health Management Marieke Adriaanse and Professor of Health Psychology Andrea…

IBL-researcher Phil Elks in the group of Annemarie Meijer won the Cell Observatory Publication of the Year 2013. He received the award for his paper in PLoS Pathogens, showing that activation of hypoxia signaling protects against mycobacterial infection.

PhD defence

Lecture

Prof. Jaap van den Herik was a guest in the latest episode of the Nationale Data Podcast.

Mirjam Sombroek, Aart Hendriks and Martine de Vries (LUMC) will work on mapping the ethical and legal aspects of gene therapy. The aim is to establish a best practice of how society can best deal with these therapies. For example with guidelines on how to regulate, reimburse and make these therapies…

Lecture

Five research projects of the Institute for History have been selected for the Research Traineeship Programme 2016-2017. The programme was initiated by The Faculty of Humanities to offer motivated students the opportunity to develop themselves in academic research. In December the research trainees,…

A delegation from Leiden University recently embarked on a knowledge mission to various NGOs, universities and government organisations in Indonesia. New partnerships were formed and important knowledge exchanged, and researchers from Leiden gave guest lectures.

Lecture, LIAS Lunch Talk Series

PhD student Esmee Koedoot studied the underlying processes responsible for metastases in a dangerous type of breast cancer. She hopes to find new possibilities to fight the disease. In December 2019 she obtained her doctorate cum laude.

In 2019, the European Parliament and the Council adopted the Preventive Restructuring Directive (2019/1023), providing for minimum harmonisation of, among others, preventive restructuring frameworks (PRF). This book, published in February 2024, provides in-depth analyses of its implementation in seven…

Social resilience and security has never been more important. Over the last 2 years, the COVID-19 pandemic has created a considerable disturbance to our personal and social lives. As a result, the general population reports more stress, loneliness and decreased quality of life. At the same time, there…

Join-in courses zijn MA-cursussen over middeleeuwse onderwerpen gegeven binnen vastgestelde MA-programma's van de zes deelnemende universiteiten van de Onderzoekschool. Op aanvraag zijn deze vakken toegankelijk voor studenten van andere (Nederlandse) universiteiten. De cursusbelasting en het aantal…

On young Muslims seeking to understand their place and make their way in a transformed world.

Cigdem Oguz defended her thesis on 13 June 2018

In this book Adam Fairclough chronicles the odyssey of black teachers in the South from emancipation in 1865 to integration one hundred years later.

The Tatiana Afanassjewa-lecture series was a series of public talks in Dutch that was started during the Covid-19 lockdown. The talks were given by Leiden physicists on wednesday evenings, intended for everyone with an interest in physics.

Leiden’s Institute for History has an exceptionally strong expertise in premodern European history in its global context, with specialists whose interests cover virtually the whole continent.

On 9 June 2020, Maral Darouei defended her thesis 'Managing a sustainable career in the contemporary world of work: Personal choices and contextual challenges'. The doctoral research was supervised by Prof. J.I. van der Rest.

How do old and new Information and Communication Technologies (ICTs) relate to new social and political movements in Central Africa? What does this tell us about Africa and the Information Age?

The National-Socialist Movement in the Netherlands - the NSB - remained the only legal party in the Netherlands during most of the Second World War.

To get an idea of the science communication products and research that is possible, a few examples of student projects of recent years are shown below.