PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

Researchers from the Leiden University Medical Center (LUMC) are working on the first diagnostic test for leprosy that can be used outside a laboratory. This will not only reliably diagnose leprosy, but also be cheap and easy to use. Leprosy mainly occurs in low-income countries. A double challenge…

The Japanese Studies community at Leiden University is deeply saddened by the sudden loss of our colleague, Erik Herber. He was not only an esteemed scholar and teacher, but also, to many of us, a dear friend.

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

Promotor: Prof.dr. T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn, Co-promotor: Dr. M.J.M. Schaaf

Promotores: J. Jonkers, K.E. de Visser

This study stresses the importance of investigating vitamin D deficiency in every community to better understand the deteriorating effect that sociocultural practices may have had on health.

The ambition of the Medical Systems Biophysics and Bioengineering group led by Alireza Mashaghi is to develop and use physics and engineering concepts and tools for pathophysiology, diagnostics and therapy.

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

Promotores: A.H. Meijer, H.P. Spaink

Which compounds and microorganisms that live near and inside plant roots are beneficial? Can we use this knowledge to improve the health and growth of crop plants?

The indane (2,3-dihydro-1H-indene) ring system is an attractive scaffold for biologically active compounds due to the combination of aromatic and aliphatic properties fused together in one rigid system.

On the basis of the characteristic aspects of a picture, certain computers can tell us what the picture is showing. They can learn this in the same way that young children are able to learn to recognize images. Further improving these techniques opens the way to a whole range of new applications. Biology…

List of Support Departments at LION and the Faculty of Science

Does Artifical Light at Night (ALAN) disrupt seasonal physiological and behavioral patterns in migrating freshwater fish?

From as early as classical antiquity there has been an interplay between literature and medicine.

The Laboratory for Human Osteoarchaeology specialises in the macroscopic and microscopic analysis of human remains. We use cutting edge scientific approaches to address archaeological, historical, and anthropological research questions. In addition to paleopathological, histological, and 3D scanning…

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Ferritin is a spherical metalloprotein, capable of storing and releasing iron in a controllable way. It is composed of a protein shell of about 12 nm and within its cavity, iron is stored in a mineral form.

Supervisor: P.J.J. Hooykaas

MHC class I and MHC class II molecules present peptides to the immune system to drive proper T cell responses. Pharmacological modulation of T-cell responses can offer treatment options for a range of immune-related diseases.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

The BENEFIT programme is a public-private ecosystem in a national consortium, aiming to support patients with cardiovascular diseases in their own home setting for a long-term healthy lifestyle.

Can the venom of snakes, scorpions and other animals be sources of new antibiotics?

Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon

Timely, adequate and optimal treatment of infectious diseases is essential for the survival of patients with bacterial infections (Surviving Sepsis campaign).

Tuberculosis is an infectious disease which is spreaded through the air. It is caused by Mycobacterium tuberculosis and it led 1.7 million people to death in 2016. This mortarlity rate is concentrated in developing countries such as Indonesia, Philippines, Pakistan, and South Africa. These numbers make…

Animal models suggest that the chemokine ligand 2/CC-chemokine receptor 2 (CCL2/CCR2) axis plays an important role in the development of inflammatory diseases. However, CCR2 antagonists have failed in clinical trials because of a lack of efficacy.

Promotor: J. A. Bouwstra

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman

The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.

To be able to identify, slow down and reverse functional deterioration in the elderly to give them more years of good health.

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

Some species of proteins which can form liquid-like condensates, also exhibit growth into fibers (or fibrils). One particularly interesting set of such proteins are those that are associated with neurodegeneration in which the fiber growth may be related to the pathological fibrils observed in disea…

To increase clinical success rate of drugs, a better understanding of drug action mechanism and disease dynamics is required. Metabolomics, which studies small molecules involved in biochemical processes in organisms, has shown to be a useful tool for this better understanding.

The aim of this project is to develop accurate but interpretable ensemble learning methods for high-dimensional multi-domain data.

Source: Org Biomol Chem, Volume 13, Issue 8, pp. 2407-22 (2015)

On this page, you can find video's explaining the research of LUCAS members.

This project explores themes at the intersection of maritime history and environmental history by looking at the problems Dutch ships encountered in the different climates of the Atlantic and Indian Ocean worlds, and the solutions they could provide.

Can the pink-pigmented microbe Methylobacterium extorquens be genetically engineered to convert the sustainable raw material methanol into antibiotics?