Development of Comprehensive and High-throughput metabolomics techniques and Clinical applications of (pharmaco)metabolomics

Our group is part of the Metabolomics and Analytics Centre where we accompany the data from its acquisition all the way to the publication of identified associations and biomarkers for a range of human diseases. The generated data of the metabolic measurements are assessed using an in-house quality…

The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine.

The ambition of the Metabolomics and Analytics Centre led by Thomas Hankemeier is to develop innovative analytical strategies for metabolomics-driven health monitoring and systems biology studies. Understanding the intricate balance between health, disease and adaptation to challenges relies on the…

In the near future oral polio vaccine (OPV) will be replaced by inactivated polio vaccine (IPV) as part of the eradication program of polio. For that reason, there is a need for substantial amount of safe and more affordable IPV for low-income countries. Bioneedles, which are biodegradable mini-implants,…

Atherosclerosis (thickening of the artery wall) is the most common cause of heart attacks or strokes, and one of the most common causes of death in the western world. People with this condition have to take medicine all their lives, so a vaccine for atherosclerosis would be a breakthrough.

Dr. Foks obtained this fellowship for the project “Can promotion of efferocytosis induce regression of atherosclerosis?”, in which she aims to identify novel targets to promote regression of atherosclerosis. This research grant allows her to initiate independent research for the next three years.

The European PANVIPREP research project started at the Leiden University Medical Center on 11 March. The participants are virologists, biochemists and pharmacists from 14 European countries. Their mission is to develop antiviral drugs to protect Europe during pandemics. At least two such antivirals…

Epithelial cells play a crucial role in the lungs. PhD student Ying Wang researched the effects of cigarette smoke and viruses such as COVID-19 on these epithelial cells. ‘We hope to reduce the risk of pandemics in the future.’

The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterise and predict variation in treatment response and enhance translational drug development strategies.

Scientists at the LUMC are working hard on potential virus inhibitors, antiviral screening and a treatment for COVID-19. SteunLeiden.nl has started a crowdfunding campaign for this research, under the hashtag #wakeuptocorona. Professor of Virology Eric Snijder explains why this is desperately needed…

The Quantitative Pharmacology group headed by Coen van Hasselt focusses on the application of state-of-the-art quantitative pharmacometrics and systems pharmacology modeling combined with translational experimental models to develop personalized treatment strategies for antibiotics and to combat antimicrobial…

Leiden has a long history in the treatment of blood cell cancer. Research to find better therapies never stands still. One of the potential treatments currently being worked on is a ‘living medicine’.

Research in the Daniela Kraft Lab focuses on self-assembly in biological and soft matter systems, ranging from anisotropic colloidal particles to lipid membranes, emulsions, and viruses.

Host-Microbe Interactions is one of the four research themes of the Institute of Biology Leiden.

Interest groups play an important role in democratic society.

Knowing how to resolve global problems is one thing, but how do you make sure that it actually happens? That’s the real challenge, because there are powerful movements everywhere that want to reconstruct the walls of nation states. In an attempt to resolve this issue, Leiden researchers are experimenting…

By detecting the tiny forces between a micrometer sized magnet and the spins of hydrogen nuclei, we can do MRI with a volume resolution that is approximately 12 orders of magnitude better than a conventional MRI.  

Fake news about ‘patient zero’ and hyperbolic headlines warning about the ‘yellow peril.’ Leiden researchers have spotted fake news galore about coronavirus as well as racial stereotypes about the Chinese. How harmful is this?

If you'll soon be getting a COVID-19 vaccine, you might just get the Johnson & Johnson (Janssen) one. This vaccine was developed for the most part in Leiden – and this is no coincidence. Watch the animation below about the development of one of the vaccines in the fight against COVID-19.

Infecting each other with viruses and bacteria while protecting yourself with medicines and vaccinations. Sounds like a fun evening, right? Master students Life Science & Technology Rafael Jezior and Dennis de Beeld certainly think so. Together, they developed ImmunoWars: an exciting card game based…

We are confronted on a daily basis with news about the Corona virus and its consequences. We read alarming headlines like 'Dutch becoming increasingly anxious about Corona virus' or 'Huge fears and stress about Corona crisis'.

Important note: upon careful consideration, we have decided to resume our Dutch language courses.

A single tiny molecule that can destroy flu, corona, HIV and Zika viruses? Yes, it really does exist. Biophysicist Niek van Hilten, who will receive his doctorate on 14 September, contributed to this discovery.

The research group of Eric Snijder, Professor of Molecular Virology (LUMC), has been conducting research on coronaviruses for decades. Then in March this year their work accelerated at an unprecedented rate. The first new results are now available: insight into how the virus replicates.

What do I do if Mum or Dad gets the virus? Could the slide at the playground have coronavirus on it? Can children die of the virus too? On 15 April, the National Science Agenda organised an hour-long session on Facebook to give children the chance to ask their questions about coronavirus. Leiden psychologist…

Jelle van Buuren, Assistant Professor at Leiden University, appeared in Dutch newspapers the Algemeen Dagblad and Het Parool to discuss conspiracy thinking and the pandemic.

An overview of awards and prizes granted to our staff and students in 2019, as well as special appointments and royal distinctions.

Researchers need to work in specialized environments when they work with dangerous bacteria and viruses. These microbes spread easily, so only in labs with a high biosafety levels they can be studied. Unfortunately, to look at the microbes properly, expensive microscopes are needed that are not always…

Prehistoric people may well have had an emotional bond with domesticated dogs much earlier than we thought. Leiden PhD candidate and vet Luc Janssens discovered that a dog found at the start of the last century in a grave dating back 14,000 years had been sick for a long time and had been cared for.…

At the end of the year we always compile a list of our most interesting, most popular articles from that year. In the crazy year that was 2020 one topic was at the forefront of everyone’s minds: coronavirus. Fortunately, there was also room for other stories.

Researchers Indu Khatri, Frank Staal and Jacques van Dongen from Leiden University Medical Center (LUMC) have published a perspective article in Frontiers in Immunology about coronavirus and its characteristic ‘spike protein.’ They predict which antibodies would provide the best protection against the…

The end of October will be all about the United Nations (UN). The festivities for the 75th anniversary have been scaled down due to the corona virus. 'A shame', says Prof.dr. Alanna O'Malley, but at the same time she sees that corona crisis also offers opportunities for the UN.

Gathering and distributing patient data can make an important contribution to containing the coronavirus. But if we want to be successful, we need better data. With this objective in mind, Leiden data stewards have joined the Virus Outbreak Data Network (VODAN).

At the end of March, the first coronavirus infections were detected in southern Africa, which resulted in country after country rapidly closing their borders. Tycho van der Hoog witnessed this process at first hand during his PhD research in Namibia. He analyzes the state of the corona crisis from his…

Leiden Asia Centre researcher Anoma van der Veere argues that the Japanese government has failed to respond properly to Covid-19. There were difficulties with implementing government measures aimed at limiting the spread of the virus – in some cases those measures were not even taken seriously. How…

The infectious diseases malaria and tuberculosis are responsible for 2.1 million deaths every year. Leiden researchers are currently testing a new tuberculosis vaccine.

Vaccines are an extraordinary category of biopharmaceuticals. They are usually prophylactic and come in many types, from whole bacteria to peptides and nucleic acids. They are very cost effective and almost every human on the planet is vaccinated. The latter mandates that vaccines have to be extremely…

Development & Disease is one of the four research themes of the Institute of Biology Leiden.

The research in the Biosyn group is focused on the design, synthesis and function of the four major types of biomolecules: nucleic acids, carbohydrates, peptides and lipids and hybrid structures thereof. These biomolecules and their derivatives are used in drug discovery and chemical biology, to develop…

The CADS Research Cluster People, Power and Diversity aims to further theoretical and methodological debates on the classifications of human difference, such as gender, race, ethnicity, sexuality, class, age, ability, religion, level of development, time, etc., and the way these classifications organize…

The master’s programme Statistics & Data Science provides students with a thorough introduction to the general philosophy and methodology of statistical modelling and data analysis. The programme has two specialisations: Data Science and Statistical Science.

Dr. Kirsten Leiss and Prof. Peter Klinkhamer received 900.000 euro’s from “Stichting Toegepaste Wetenschappen (STW)” and the company “Rijk Zwaan” to develop plants that are resistant to thrips, a major agricultural pest all over the world.

Almost all PhD defences at Leiden University have been postponed due to the corona virus, but statistician Sanne Willems is going through with hers. In a different form than usual that is. Hardly any audience, the committee dialing in from a distance and the celebration to be held at a later moment.…

LUMC research has shown that women who previously had a miscarriage due to COVID-19 are not at increased risk of having another miscarriage or a stillbirth. Nor are preventive drugs needed during the pregnancy.

The Department of Medical Microbiology of Leiden University Medical Centre (LUMC) will investigate the efficacy of a new experimental vaccine from the pharmaceutical company Jansen against the coronavirus. The research is being conducted in collaboration with the The Janssen Pharmaceutical Companies…

Unfortunately, Covid-19 won’t be the last infectious disease to sweep across the world. To nip such diseases in the bud, a team of Leiden students is developing a test kit that will be able to detect infectious diseases at an early stage. With this idea, they won the Grand Prize of the international…

How are Dutch universities working together in times of corona, and which solutions are they offering? On 15 May VSNU chairman Pieter Duisenberg presented the e-zine ‘Universities in times of corona’ (LINK) to Ingrid Van Engelshoven, Minister of Education, Culture and Science. The e-zine contains a…

On April 8th 2020, Ivan Romashchenko successfully defended his doctoral thesis on 'Related party transactions and corporate groups: When Eastern Europe meets the West'.