This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.

List of Kloosterman professors

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

Quantum computing is a novel paradigm for computation, which is nearing real-world impact with the coming generation of limited, but nonetheless powerful quantum devices.

The following students have been part of LAPP:

For many years, scientists have observed a correlation between Alzheimer’s disease and a surplus of iron in the brain. However, a causal link between the two has not been proven yet. We lack knowledge concerning the specific form of iron that is involved in the development of neurodegenerative diseases.…

Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…

How do crises produce changes in specific European Union foreign policy areas, and how should we conceptualise these policy changes?

Identifying and explaining change in the structure of central state bureaucracies and the determinants of survival of individual public organizations are two closely related areas of research in public administration. We aim to bridge the gap between these two main strands of studies of organizational…

Optimality in plant properties and processing.

African oral literatures, new media and technologies: challenges for research and documentation

As Lila Abu Lughod pointed out in 1989, North Africa has been one of the geographical ‘zones of prestige’ for the development of canonical approaches and crucial theoretical debates regarding the comparative study of Islam.

The gripping story of a collective passion for freedom that shook the world.

Can drug screening for tuberculosis treatment be made more efficient?

This project has two main aims: I. Determine when novelty promotes fear extinction. II. Discover the neurobiological mechanisms underlying these effects.

We investigate reaction systems, a novel computational model gleaned from the biochemical reactions taking place in living cells and information processing in nature.

Do you enjoy a great story? In the Bachelor's programme Film and Literary Studies at Leiden University you study the stories behind the stories. Because what makes a novel fascinating or a horror movie frightening? Study film, literature and media from around the entire world and discover the differences…

Promotor: Prof.dr. T. Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto

Research at the Leiden University Medical Center (LUMC) Department of Pathology shows the power of artificial intelligence (AI) applied to endometrial carcinoma microscopy images. The group of Dr. Tjalling Bosse offers novel insights that could improve diagnosis and treatment of uterine cancer. Their…

How can we find novel natural products from Actinomycetes that act as growth modulators on mammalian cells? Can we harvest and develop the potential of these novel compounds for industrial and medical biotechnology?

How can we promote more durable solutions to protracted refugee situations and which roles can connectivity and mobility of displaced people play to improve protection and resilience?

Political Islam is not new to the Middle East, but the appearance of ISIS has stretched the phenomenon to the extreme.

One of the most crucial aspects of our behaviour is our motivation to explore novel environments and interact with new people. This became painfully clear during the COVID-19 lockdowns, when many people suffered from lack of new experiences and real-life social interactions. The relevance of novelty…

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

Promotor: Prof.dr. E. Deprettere

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

A plasma is an ionized gas with very low electrical resistivity. As such, magnetic field lines are 'frozen in' and move with the fluid. Magnetic field lines that are linked, knotted and tangled, cannot be undone by the fluid motions.

Subproject of

Anybody can imagine how difficult it is to read a 2000 years old text for the first time. It is almost inevitable that at first mistakes are made in deciphering and interpretation. This is why revision and correction of published texts play an important role within Papyrology.

The formation of stars and planets happens over multiple scales, which can interact. In particular, planet formation happens in the dense, complex environment of star forming regions.

Why obey the state? Dorota Mokrosińska presents a fresh analysis of the most influential theories of political obligation and develops a novel approach to this foundational problem of political philosophy, an intriguing combination of the elements of natural duty and associative theories.

In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

This research develops and applies a new approach to study Aegyptiaca Romana from a bottom-up, Roman perspective.

This paper develops a novel theoretical framework for the conduct of postmortems after major foreign policy surprises for the European Union and its member states.

There is no heritage without emotional sharing and clashing. This article explores the involvement of divergent emotions in heritage making by discussing the debate series of Imagine IC and the Reinwardt Academy and zooming in on the commemoration of slavery and imagery of ‘Black Pete’ in the Netherlands.…

Terms used by literary critics in characterizing the style of novels are often impressionistic (‘baroque’, ‘austere’, ‘vivid’, ‘cerebral’ etc.). Foundations for such evaluations are usually not provided. A scientific way of studying and explaining style is lacking in present day Dutch Studies. Suzanne…

In 1989 the Board of Governors and the Council of Leiden University granted the establishment of a special Chair for Central European Studies with a focus on Austria: 'Lehrstuhl für mitteleuropäische Studien mit besonderer Berücksichtigung Österreichs'.

Thomas Mes defended his thesis on 9 January 2018.

Effectiveness of an early intervention program for anxiety-prone toddlers in the Netherlands

How do teachers conceptualise, develop and implement an effective CLIL practice?

Százhalombatta-Földvar is a Bronze Age fortified tell settlement on the right bank of the river Danube, 30 km south of Budapest in Hungary. It is one of the best preserved temperate climate tells in Europe and well-known for the extraordinarily rich data it produces. Since 2014 Leiden students are welcomed…

The research group on governance of crises studies phenomena, dynamics and actors related to crisis governance. The Leiden University Crisis Research Center (CRC) is part of this Research Group.

Corporate R&D organizations and their relation to academic laboratories.

Promotor: J.P. Abrahams, Co-Promotor: N.S. Pannu

Introduces a novel trope of photographic images dealing with states of mental disorders; focuses on photographs that visualize disturbed corporeal and mental perceptions of the world and connects medium-specific characteristics of photography to concepts from mental disorder studies.

Source: Br. J. Pharmacol., Volume 172, Issue 3, pp. 940-55 (2015)

To explore the potential of marine microorganisms as producers of novel antimicrobial agents and as bioprotectants in aqua- and agriculture, using an integrative, ecology-based strategy for bioprospecting.

PhD defence

Microbial rhodopsins are photosensitive pigments implemented in the growth and adaptation of a large population of microorganisms.