IBL-researcher Phil Elks in the group of Annemarie Meijer won the Cell Observatory Publication of the Year 2013. He received the award for his paper in PLoS Pathogens, showing that activation of hypoxia signaling protects against mycobacterial infection.

PhD defence

Lecture

Lecture

Keep improving: that’s the philosophy of LEAN, a method to tackle practical problems at the workplace yourself. After a successful start in 2017, in 2019 a third group started working with the LEAN training in self-selected improvement trajectories. In October the participants received their diploma.…

The Faculty of Archaeology's own home-grown journal Inter-Section has released a new volume. Inter-Section offers students and PhD candidates the unique chance to publish in a peer-reviewed journal. Karel Kuipers and Tullio Abruzzese contributed to the new volume.

Frans Preumayr's nineteenth century virtuosic bassoon repertoire - An approach with a fine Grenser & Wiesner bassoon from Dresden: Issues of material and technique. What techniques and tools must be developed by period bassoonists in order to successfully approach the performance of Frans Preumayr's…

Salma Balazadeh, Víctor Carrión, and Jos Raaijmakers, biologists at the Institute of Biology Leiden (IBL), have successfully applied for an NWO grant and got awarded 730.000 euros. The board of NWO Domain Applied and Engineering Sciences awarded funding for their project within the Open Technology Programme…

In the Leiden University Medical Centre (LUMC) we strive to improve health care and the health of people.

In this inspiration lab, Prof. Sandra Groeneveld and Matthijs de Jong (Deloitte) will share their vision on the Future of Work. What are the trends and developments in the fields of Organisation Theory and Human Resource Management? What is the impact on unemployment rates? And what is the impact on…

The doors of the new Gorlaeus Building are officially open! With an additional lab wing, new lecture halls and offices, a library, a brasserie, and spaces for student associations, the building offers a vibrant and inspiring environment for research, study, and social interaction. Explore on your…

Science

The Master’s programme Health, Ageing and Society trains its students to become academic Health, Ageing and Society professionals and engaged citizens who are competent and trained internationally and interdisciplinary. They are able to contribute to solutions for the challenges facing our ageing so…

A major goal of ABS research is to overcome one of the major bottle-necks in metabolomic research: the lack of a high-throughput infrastructure in which thousands of samples can be processed in a standardized and cost-effective way (max. a few tens of Euro’s per sample for a full metabolome profile).…

Developing computational algorithms for structural biology -A high resolution, three dimensional view of a molecule provides detailed information that help elucidate its function: by knowing the exact arrangement of atoms in a molecule, we can understand disease, develop drugs to combat them and improve…

What are the main factors associated with the stranding of the two seal species? What are the factors influencing the prevalence of disease in the two species? Which human-related factors influence the populations of the two seal species?

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model

Dementia is a progressive disease, diagnosed at a relatively late stage when intervention may not be effective. Aim of the research is to study scans of brain networks to help discover the early network changes related to dementia. Early diagnosis may benefit effectiveness of future treatment.

In Microbial Sciences, we perform multidisciplinary research to understand the structure and function of microbes at all levels of biological organization, from small molecules and cellular structures at atomic resolution to multicellular communities.

Our everyday life consists of all sorts of spatial processes: we find our way to work, remember where we left our keys, and are able to pick up our cup of coffee. We study how the human brain processes such spatial processes. From a clinical perspective, we are interested in how acquired brain damage…

Proteases degrade matrix molecules in the atherosclerotic plaque, thereby reducing atherosclerotic plaque stability. Mast cells, that contain proteases such as tryptase and chymase, have been identified at the site of rupture in specimens of human coronary arteries and their number in the plaque was…

This study aims to examine how South Korea (hereafter, Korea) and Japan, two neighboring countries in Northeast Asia, have been responding to and mitigating the spread of COVID-19.

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska

Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

Smartphone behaviors are so common but how does the brain generate this behavior? The Cognition in the digital environment laboratory (CODELAB) investigated the brain activity surrounding smartphone interactions with the help of Artificial Intelligence. According to their research, the brain fluidly…

Netherton Syndrome (NTS) is a rare genetic skin disease caused by mutations in the serine protease inhibitor Kazal-type 5 gene, which encodes the lympho-epithelial Kazal-type-related inhibitor. NTS patients have a profound impaired skin barrier function. Because SC lipids play a crucial role in the…

If a new method has been developed to recognize and treat a (neuro-)psychological disorder or related behavioral factors, it cannot yet be used directly in clinical practice. First, the method should be evaluated, preferably in randomized controlled trials.

Agriculture is among the most vulnerable sectors to climate change and poorer countries face the most severe difficulties. Coffee farmers in Central America, for instance, are facing multiple and mutually reinforcing crises, including price shocks, outbreaks of pests and diseases, migration, and farm…

Bachelor and Master students of all chemistry related studies are more than welcome to take part in our research activities. We have projects on design and synthesis of biologically relevant compounds within an ongoing research project. Supervision, following the apprentice/teacher model, is one of…

Source: Eur J Med Chem (2015)

The barrier function of the skin is primarily provided by the stratum corneum (SC), the outermost layer of the skin. Skin barrier impairment is thought to be a primary factor in the pathogenesis of atopic eczema (AE).

OBJECTIVES: To determine whether the lipid/protein ratio and the total dry SC mass per surface area are related with the skin barrier function of controls and AE patients.

Developing a clinical decision support tool that will make it easier for clinicians to personalise the treatment for patients with high blood pressure. The team is using AI, deep learning methods and patient cohort data from 11 European countries.

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

Promotor: M. Danhof, Co-promotores: J. Freijer, A. Yassen

The master's specialisation Molecular, Cellular and Organismal Biology at Leiden University examines the molecular mechanisms underlying health and disease and how cells and organisms adapt to environmental factors.

In the master’s specialisation Molecular Genetics and Biotechnology at Leiden University students are trained by experts in the areas of molecular biology, microbiology, plant genetics, cellular imaging, animal disease models, and various –omics technologies and the corresponding bioinformatics.

The Translational Immuno-Pharmacology group works on translating the efficacy of anti-infective therapy from preclinical (e.g. in vivo) to clinical, and is led by Rob van Wijk. Infectious diseases, such as tuberculosis, are in constant need of new therapies that work better, faster, and with less risk…

Research into the evolutionary backgrounds of our diets can help us make the right choices in diet, health and lifestyle.

Key publications of the Aging and Immunity group

In order to optimize treatment, it is necessary to closely monitor and manage the patient’s health status by means of ‘precision diagnostics, personalized prognosis and targeted therapy’. The specialisation combines the techniques and applications of these sensing (monitoring) and stimulation techniques.…

The Biomedical Metabolomics Facility Leiden (BMFL) is the core metabolomics facility of Leiden University and the Metabolomics and Analytics Centre (MAC). We offer a highly structured environment for advanced MS-based metabolomics studies and build on fully validated, state-of-the-art assays that each…

In the Biomedical Sciences Education specialisation you gain knowledge and skills in the area of teaching in biology. The education specialisation is for students who want to work as a first-grade teacher Biology at secondary education or for those who want to specialize in education in general. Since…

The below schedule gives an overview of the curriculum of the one year fulltime master's programme Health, Ageing and Society for 2024-2025.

This book explores how public health concerns and political agendas influenced each other in the US over the past century.

PhD defence