3,431 search results for “paul 1992 1990 disease worked” in the Public website
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Single-cell mechanics for disease biology and pharmacology
PhD defence
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Genetics and Life Course Epidemiology of Cardiometabolic Disease
PhD defence
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Atherosclerotic cardiovascular disease: Interplay between sex, age, and circadian rhythms
PhD defence
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4D-Flow MRI of Aortic and Valvular Disease
PhD defence
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Oxidants and antioxidants as targets for cardiovascular disease prevention
PhD defence
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glycocalyx; a diagnostic and therapeutic target in cardiometabolic diseases
PhD defence
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Metabolomics to predict progression in chronic kidney disease
PhD defence
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From data to models: reducing uncertainty in benefit risk assessment: application to chronic iron overload in children
M. Danhof, Co-promotor: O.E. Della Pasqua
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Outreach
The Leiden Institute of Chemistry organises and participates in several programmes for high school students and teachers.
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Unspinning chromatin: molecular mechanisms of chromatin remodeling
How do you fit two meters of DNA in a tiny compartment and at the same time are able to access the right parts of it at the right times?
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The Netherlands X-omics Initiative
The Netherlands X-omics Initiative is a new facility as part of the National Roadmap for Large-Scale Research Infrastructures. It is partly funded by NWO with a total budget of 40 million euro. The project started on September 2018 and will last for ten years.
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A much-needed new class of antibiotics
Antimicrobial resistance (AMR) is the phenomenon that pathogens become insensitive to the antibiotics that we use against them. A growing number of pathogens is becoming resistant, with methicillin-resistant S. aureus (MRSA) as the most famous example. But while the threat of AMR represents a slow-moving…
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Mast cell-mediated immune modulation in experimental Rheumatoid Arthritis and Atherosclerosis
In this research project, we aimed to obtain more insight in the role of mast cells in the immune driven disorders rheumatoid arthritis and atherosclerosis.
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Evolutionary adaptability of β-lactamase: a study of inhibitor susceptibility in various model systems
β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…
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Utopia: Universal Three-dimensiOnal Passport for process Individualization in Agriculture
Agricultural foods naturally vary in their detailed internal structure. To facilitate early detection of health hazards due to contamination or disease, predict maturity and minimize wastage, it is critical to take into account the internal characteristics of each individual product, as these enable…
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Medicine/Leiden University Medical Center
We are very happy to welcome you to spend a semester or year studying or doing an internship with us at the Leiden University Medical Center. Here you will find information on your course timetables and registration.
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Single cell technologies for mechanobiology and mechanopharmacology
Mechanobiology is a major area in biology, however, mechanics is currently a missing element in drug development pipelines. This has led to a high cost for the society. Mechanotoxicity of drugs often appears as a long-term side effect of drugs, and has led to removal of drugs from the market. Furthermore,…
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Impact and city
Leiden University and the city of The Hague are working closely together to increase the impact of our research and education in order to contribute as much as possible to the development of the city.
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Cannabinoid receptor 2 as a ‘drugable’ target: kinetic profile of novel receptor ligands
Supervisor: Andrea Martella
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Bioactive Molecules in Microbial Sciences
Microbial Sciences' contribution to the Bioactive Molecules research theme is to discover new bioactive molecules and enzymes and unravel their mechanisms of action, regulatory networks, and the (bio)synthetic pathways required for their production.
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Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.
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A novel formulation for skin barrier repair : from ex vivo assessment towards clinical studies
The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.
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European Energy, Environment and Health
Research on this theme addresses the systemic risks faced by European societies and affecting the quality of life of European citizens.
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Unraveling temporal processes using probabilistic graphical models
Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.
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Institutes
All research at Leiden University is organised into institutes. To do justice to the wide spectrum of research (and consequently teaching) that comes from these, you will find descriptions of all the Leiden institutes on these pages.
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Transcultural Health Care Utilisation in Serengeti of Tanzania: Towards Applied Ethnoscience in Public Health Management
The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.
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Grant: Dr. Amanda Foks receives a prestigious Junior Postdoc fellowship from the Dr. E. Dekker stipendium awarded by the Dutch Heart Foundation
Dr. Foks obtained this fellowship for the project “Can promotion of efferocytosis induce regression of atherosclerosis?”, in which she aims to identify novel targets to promote regression of atherosclerosis. This research grant allows her to initiate independent research for the next three years.
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Highly sensitive analysis using 3D cell culture model
A research goal for ABS is to develop miniaturized platforms for research in (stem)cell, in-vitro systems and application in clinical and preventive research. Combined with the high throughput, this development will make it possible to study the dynamics of pathogenesis in human and cellular models…
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Lipid model membrane systems as a tool for unraveling the underlying factors for skin barrier dysfunction
Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.
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Kinetics for drug discovery – The first step towards an improved drug discovery paradigm
Supervisor: Indira Nederpelt
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Vaccination and Targeted Therapy Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.
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Cancer Drug Target Discovery
In this research group, headed by Prof. Erik Danen, the aim is to unravel cellular signaling mechanisms in normal and diseased cells, with a long-standing interest in cell adhesion signaling. In complex multicellular organisms such as ourselves, a division of labor emerges where different tissues and…
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We all BENEFIT: The Ecosystem for Healthy Living
The modification of risk factors and related health behaviors lies at the very core of adequate cardiovascular risk management, yet evidence shows that the majority of people with cardiovascular disease (CVD) fail to achieve a healthy lifestyle in the long term. The main objective of this project is…
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e-Coach: Tailored cognitive-behavioral e-Health care for patients with chronic somatic conditions
The major aim is to develop, evaluate, and implement disease-generic cognitive-behavioral interventions through the internet in order to optimize tailored health care for patients with chronic somatic conditions.
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The Secular Outlook
The Secular Outlook describes what moral and political secularism means. It paints the image of a world view in which state and religion are kept well separated.
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‘We’re not only studying society, we’re creating society’
Students, staff and alumni of the Faculty of Social and Behavioural Sciences joint forces to interact, debate, pitch, and speed date together at the Connecting Social Sciences science festival on Friday 22 November, 2019. After the opening speeches and panel discussion on science and societal impact,…
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Who are the Squatters? Mapping and documenting squatting in Leiden as a cross-over project between Public History and Academic Research
This project sets out to map, document and analyze instances of squatting in Leiden from 1970 to 1990, in order to set up an online Digital Archive of Squatting in Leiden. This archive will function as an online resource for academic research, as well as a starting point for public activities such as…
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Making fuels from sunlight and CO2
Plants could be regarded as small chemical factories, which produce chemical substances via photosynthesis. If we can imitate photosynthesis in an artificial system, we can make clean fuels and materials out of sunlight and CO2. Huub de Groot is very close to designing a system of this kind.
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Parts of the Sum. Dutch provincial identities 1747-1850
Between 1798 and 1813 successive regimes attempted to enforce a fundamental geographical and administrative redivision of the Netherlands. The provinces that had been sovereign states within the Republic of the United Netherlands for over two centuries were dissolved and replaced by ‘departments’, subordinate…
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Life in Custody Study (LIC)
The Life in Custody (LIC) Study comprises a large-scale research project into prison climate and the quality of prison life in Dutch prisons.
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and Authority in Late Antique Egypt: Bishops of the Theban region at work
Renate Dekker defended her thesis on 7 November 2017.
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On imagination in science: ‘A good researcher is also an inventor’
As far as Daniël Pijnappels, Professor of Cellular Electrophysiology, is concerned, both researching and inventing are essential for a scientist.
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Annemarie Meijer new training coordinator in European network
The new project INFLANET will train young scientists in Europe to become experts in inflammation research. Professor Annemarie Meijer from the Institute of Biology Leiden coordinates the training.
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ARC (art_research_convergence)
ARC (art_research_convergence) is an outreach initiative of Leiden University Academy of Creative and Performing Arts, and the University of the Arts The Hague, for the active communication of artistic research.
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Better reading comprehension
How can we help children and adults to acquire better reading comprehension? Paul van den Broek and his colleagues at the Brain and Education Lab are searching for an answer to this question by investigating reading and the related brain activity.
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Scholarly Vices: A Longue Durée History
This project tries to explain the persistence of this cultural repertoire by zooming in on (1) interaction between idioms (cultural repertoires) available to scholars at certain points in time, (2) mechanisms that help transmit repertoires across time and place, and (3) rhetorical purposes for which…
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Construction work starts on new accommodation for international PhDs
Work has begun on an accommodation complex for international PhD candidates and postdocs at the Leiden Bio Science Park.
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Indonesian 'coffee plant' named after Leiden researcher
Research on Asian plants is his life's work. Now a crown is added to that: a plant from the coffee family bearing his name. Paul Kessler is LUF professor of botanical gardens and botany of South East Asia and Scientific Director of the Hortus botanicus. 'Completely unexpectedly, you get to see the results…
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Gender and Agency in Careers: The Work-lIfe Experiences of Women Employed by Japanese and South Korean Firms
On Wednesday 14 February 2024 Yorum Beekman successfully defended a doctoral thesis and graduated.
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Conceptualising and developing the practice of CLIL teachers
How do teachers conceptualise, develop and implement an effective CLIL practice?