Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

The European Lead Factory has been created with the ultimate goal to develop lead drug candidates to address neglected diseases including bacterial infections, psychiatric disorders and oncology.

The division of BioTherapeutics consists of the former divisions Biopharmaceutics and Drug Delivery Technology.

The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB2R, their selectivity, molecular mode of action and pharmacokinetic properties have…

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

What are the functions of the endocannabinoid system?

The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…

The HOPES study is one of the largest investigations of this kind to date! By studying existing brain scans and data collected form over 4,000 14-25 year olds, the project team hopes to identify specific changes in the brain that make young people vulnerable to suicidal thoughts and behaviours.

Large numbers of children all over the world face significant health risks, such as infectious and chronic diseases, malnutrition, injuries and the consequences of natural disasters, protracted armed conflicts and poverty.

The unit Health, Medical and Neuropsychology offers eduction and conducts research on related fields of Health, Medical and Neuropsychology.

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterize and predict variation in treatment response and enhance translational drug development strategies.

The Horizon 2020 project Sybil-AA (Systems Biology of Alcohol Addiction) focuses on modeling and validating disease state networks in human and animal brains for understanding pathophysiology, predicting outcomes and improving therapy in alcohol addiction. Alcohol addiction, the most severe form of…

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

This study aims to explore the use of a behavioral-design-based approach in simulating patient flow through EMTs. It provides a dynamic behavioral simulation model to assess the interactions between patients, staff members, and the related dynamic movements/interactions with the health care facility,…

Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…

The aim of the research programme Systems Pharmacology lies in the development of personalised medicine strategies, and development of new systems-based approaches in translational and clinical pharmacology.

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Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Decision support tool for cell therapy commercialization and business development

Symposium & Workshop

Researchers need to work in specialized environments when they work with dangerous bacteria and viruses. These microbes spread easily, so only in labs with a high biosafety levels they can be studied. Unfortunately, to look at the microbes properly, expensive microscopes are needed that are not always…

An overview of research projects at the Predictive Pharmacology group.

Professor of Ultrastructural Biology Ariane Briegel has received a grant in the NWO Open Competition Domain Science in the XS category. This grant emphatically encourages curiosity-driven and bold research with a maximum of 50,000 euros.

There are around 300,000 people in the Netherlands who donate blood on a regular basis. Women can give blood up to three times a year and men up to five times, resulting in approximately one million blood donations each year. Patients that receive this donated blood are already in a vulnerable condition,…

Theft, prostitution, fortune-telling or murder. Historian Manon van der Heijden and a group of students are researching court records from The Hague from 1600 to 1800. They are tracing crimes and offenders and shedding new light on The Hague’s Gevangenpoort (or Prison Gate). Among their many discoveries…

This 48-month project is to contribute to a solid, accessible, domestically owned knowledge base for people-centred interventions aimed at strengthening access to justice in Libya (A2JiL), and to disseminate such knowledge among stakeholders, enhancing awareness and the capabilities required to provide…

Immunologist Leender Trouw specialises in the complement system, which is part of the immune system. In some diseases drugs help activate or inhibit this system. This is best done ‘in the right place at the right time’ − the title of his inaugural lecture.

This programme aims to identify the intellectual contexts that were of importance for the architectural theory of the period, and especially to clarify the relation of architectural theory to primitivism.

The SNP genotyping line offers flexible genotyping for small and large projects at affordable price and high quality. The use as SNPs as molecular markers is very versatile and can be used for a wide variety of scientific questions ranging from paternity analysis, conservatuion genetis towards QTL…

PhD defence

LeidenGlobal Workshop

PhD candidate Maia Casna received an Incentive Prize from the Dutch Association for Physical Anthropology (NVFA). She was rewarded this honor for her innovative research into respiratory diseases and her talent for presenting her results to both academic and general audiences. ‘It feels really nice…

Starting 1 November, the Walaeus Library, located in the Leiden University Medical Centre, is part of Leiden University Libraries (UBL).

Paul van Trigt and Anna Derksen, both researchers in the project 'Rethinking Disability', received grants for research abroad.

We aim to provide new insights relating to the spectacular multi-cellular life cycle of streptomycetes and other actinobacteria.

How humans and rats cohabit the cityscape and what consequences this has for both sides of the conflict?

From colonial times through to the present day, large numbers of Javanese have left their homes to settle in other parts of Indonesia or much further afield. Frequently this dispersion was forced, often with traumatic results.

The research that is united in the Liveable Planet programme, touches upon a wide range of aspects of human life. The goal is to deepen and expand the scope and to connect more researchers. The following case studies are examples of current research projects.

This dissertations studies state-society relations in 1930s Turkey, focusing on the anti-veiling campaigns in the mid-1930s and aiming to understand the ways in which the Kemalist policies were received, interpreted, negotiated, compromised and/or resisted by various actors in the provinces.

LIACS is partner in the project 'Stereotyping in Computer Science.' The project is a collaboration between multiple universities and the Dutch national expert organization on girls/women and science/technology (VHTO), which will investigate the stereotypes that children hold about computer scientist…

The central aim is to systematically study differences in crime patterns and social control between migrants and non-migrants in early modern Frankfurt am Main.

For the first time, a group of international and interdisciplinary researchers led by Karline Janmaat and her former MSc Student Chirag Chittar, have tested the several hypotheses on music simultaneously in a modern foraging society during their daily search for tubers – their staple food. They found…

Our research deals with the deep history of Europe and Eurasia, from the inception of farming up until the beginning of the Roman Period. This was a period in which key developments took place that had a profound impact on European landscapes and society until the present day. Our research and teaching…

WIIS-Netherlands (WIIS-NL) is an affiliate of WIIS Global. WIIS-NL subscribers include: professionals, civil servants, academics, NGOs, employees of international bodies and organizations, embassy staff, politicians, students, and interested members of the general public. The Chapter’s base is Leiden…