Industrial Ecology

Do humans and zebra finches share cognitive mechanisms that are important for speech perception?

Sevil Cakir-Kilincoglu defended her thesis on 18 December 2019

The focus of the dissertation

This dissertation is an experimental study of laser-generated, atmospheric pressure, transient toroidal helium plasmas.

Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…

The group is involved in training in areas of diagnostic skills, treatment/prevention/intervention, neuropsychological assessment, behavioral observations, clinical interviewing, knowledge of intellectual disability, autism, ADHD, psychosis and aggression.

Behavioral and neural mechanisms underlying risky decision-making in adolescents

On May 31st, Bobby Ruijgrok succesfully defended his doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Bobby on this great result.

Novel entities may pose risks to humans and the environment. The small particle size and relatively large surface area of micro- and nanoparticles (MNPs) make them capable of adsorbing other novel entities, leading to the formation of aggregated contamination.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

Promotor: Prof.dr. M.L. van Hecke, Co-Promotor: Prof. dr. V. Vitelli

Gibbs measures, as used in Statistical Mechanics, have a definition that is remarkably similar to the definition ofg-measures, used in dynamical systems.

Promotores: Prof.dr. B.R. Katzy, Prof.dr. K. Sailer (Munich University)

What are the mechanisms involved in the reconciliation of value conflicts and which interventions are capable of resolving such disputes?

Promotor: Prof.dr. T. Schmidt

Research groups in the Biological & Soft Matter Programme unravel mechanisms in biological processes and develop novel bio-inspired soft materials.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

The research aims to explore the evolutionary adaptability of enzymes and the impact of temperature on protein evolution pathways, using M. tuberculosis β-lactamase BlaC as the object of study. Enzymes inherently embody a delicate balance between activity and stability, and the acquisition of new enzymatic…

Researchers from Leiden University, the Netherlands, designed a novel metamaterial that buckles on demand. Small structural variations in the material single out regions that buckle selectively under external stress, whereas other regions remain unchanged. The research is published in this week’s Early…

Lecture, Tuesday Talks: Science Insights

Tuberculosis bacteria and other intracellular pathogens use cells of our immune system as Trojan horses to spread into tissues. Annemarie Meijer, professor of immunobiology, explains how research into innate defence mechanisms using zebrafish inspires novel strategies for infectious disease treatmen…

A major challenge in the formulation of biopharmaceuticals is to overcome their inherent instability during production, storage, transportation, handling and administration. We are studying underlying mechanisms of degradation of biopharmaceuticals (including therapeutic proteins, vaccines and advanced…

This thesis describes our search to identify and understand possible regulatory mechanisms of integrin α6β4 in cell-matrix adhesion and intracelular signaling.

Three major research projects involving Leiden scientists have been awarded a grant from NWO’s Gravitation Programme. The projects are on innovation processes, organs-on-chips and quantum software.

Exactly 138 years ago, Albert Einstein came into this world to forever change our understanding of it. The Leiden physics institute, where he frequently worked, organised a symposium in honor of his birthday.

Physics and Engineering Approaches to Biomedicine and Pharmacology

PhD defence

A network combining 9 academic research groups and 4 collaborating industrial companies will train the next generation of PhD students and post-doctoral researchers, in developing and applying novel experimental and theoretical methods in the NMR spectroscopy of systems containing paramagnetic metals.…

Leiden has a strong tradition in theoretical physics, thoroughly linked with experimental disciplines.

Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.

From nanoparticles to colliding ice planets and from biological origami to new x-ray scanner techniques: this year again, our scientists have made wonderful discoveries. From the largest numbers to the smallest molecules and from the oldest galaxies up to the latest algorithms, take a look at each institute's…

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

To get an idea of the science communication products and research that is possible, a few examples of student projects of recent years are shown below.

Since the early 1990s, one can isolate the optical signal of a single molecule and single-molecule spectroscopy has quickly grown into an important research field.

Artificial photosynthesis aims to produce fuels from solar energy using chemical processes. In semi-artificial photosynthesis, a hybrid approach is taken using both chemical and biotechnology approaches. We aim to develop hybrid systems between light-harvesting nanoparticles and redox-enzymes (oxidoreductases)…

Get to know us through our online and in-person events for prospective students!

Information for prospective, current and international students

The mission of our group is understanding how science communication works to improve the interaction between science and society. We believe better science communication can improve our society and engage many different groups with science, also improving science.

On this page, you will find the recordings of the online This Week's Discoveries from May 12, 2020, as well as a list of speakers since October 2015.

You’ve been accepted! Leiden University looks forward to welcoming you as a new student. Your next step is to prepare for your studies. Below you can find some tips to help you get a head start as you embark on your studies at Leiden University.

You’ve been accepted! Leiden University looks forward to welcoming you as a new student. Your next step is to prepare for your studies. Below you can find some tips to help you get a head start as you embark on your studies at Leiden University.

PhD defence

Dynamic nuclear polarization with paramagnetic agents can enhance nuclear magnetic resonance signals by orders of magnitude. The mechanism of enhancement depends a.o. on the magnetic resonance properties of the agents used. Electron spin relaxation times at NMR relevant magnetic field/microwave frequencies,…

To design the ideal water oxidation catalyst, understanding of the catalytic mechanism and decomposition pathways is essential.

In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…