287 search results for “virus” in the Public website
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Staying Ahead of the Virus
In STAYAHEAD data-intensive approaches are being developed to ”decode the human immunome” with a focus on a global vaccine strategy. They have developed a rapid mass spectrometric test to analyse in real-time large numbers of variants of SARS-CoV-2 and the host immune response, and use these data to…
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Virus-host metabolic interactions: using metabolomics to probe oxidative stress, inflammation and systemic immunity
Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken
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Global metabolomics and lipidomics approaches to probe virus-host interactions
The outbreaks of AIDS and COVID-19 showed clearly how infectious viruses can influence people’s lives. Investigating the changes in the host metabolism may provide a paradigm shift to consider immune-metabolic interactions as therapeutic targets.
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Corona virus update
Following current regulations regarding the attempts to constrain the effects of the Corona virus outbreak, the University of Leiden has cancelled all physical forms of teaching until 6 April. As conference organisers, we will use this period to consider how to proceed with the conference. In the most…
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New method of detecting rapid virus development
Physicists, including Leiden researcher, Sanli Faes, have devised a new technique for studying processes at microscale rapidly and extremely precisely. This new method will make it easier to develop antiviral medication. And it doesn’t stop there. Publication in ACS Nano.
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Ebola-on-a-chip: Leiden scientists against a fatal virus
Although Ebola is a virus with significant fatality rates, we still lack effective countermeasures to battle it. To change this, Alireza Mashaghi and his colleagues from the Leiden Academic Centre for Drug Research have successfully developed an organ-on-a-chip model that imitates the most dangerous…
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Data science can reduce likelihood of virus outbreaks
Data science is of vital importance in preventing future outbreaks of viruses, Professor of Data Science Aske Plaat argues. Inaugural lecture entitled ‘Data Science and Ebola’ on 13 April.
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Corona virus update: June conference cancelled; new date pending
Due to the by now world-wide Covid19 restrictions on travelling and holding meetings, the committee has decided to cancel the conference in June. We are now looking into postponing the conference (either to a later date in 2020 or to 2021). We will keep you informed about any further developments. All…
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How killer -T-cells migrate towards virus-infected cells
Joost Beltman (LACDR, Leiden University) has provided novel insights in the way T cells migrate towards virus-infected cells. This was accomplished by a combination of experimental research in the group of Ton Schumacher (Dutch Cancer Institute, NKI) and computer simulations in collaboration with Rob…
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T-cells more important in the fight against the COVID-19 virus than initially thought
A COVID-19 vaccine that specifically instructs the immune system to produce T-cells rather than antibodies is shown to provide good protection in a mouse model, Leiden University Medical Center (LUMC) researchers report in Nature Communications. According to them, the alternative vaccine may offer a…
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Inaugural lecture: Data science and Ebola
Today, everybody and everything produces data. People produce large amounts of data in social networks and in commercial transactions. Medical, corporate, and government databases continue to grow. Sensors continue to get cheaper and are increasingly connected, creating an Internet of Things, and generating…
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Flu stops when you block the enzyme that cleaves off virus particles
A flu virus could cause a pandemic. And then we would be poorly armed because flu viruses are starting to become resistant to flu medications like Tamiflu. Chemist Merijn Vriends successfully worked on an improved version of such medications. He will be awarded his doctorate on September 12th.
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cannot abandon coronavirus measures until vaccines are shown to prevent virus transmission too’
All acute care staff at Leiden University Medical Center have received their first and sometimes even their second dose of the coronavirus vaccine. But how long will you be protected after vaccination and what does the genetic material of the virus do in the vaccine? Our virologists Ann Vossen and Leo…
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Moritz Jesse Speaker at European Constitutionalism And the Virus of Distrust Conference in Prague
Moritz Jesse, Associate Professor at the Europa Institute Leiden, was a speaker at the International Conference European Constitutionalism And the Virus of Distrust Conference, which took place on 27 and 28 April in Prague. The Conference brought together academics from all over the European Union to…
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From field work by boat to excel sheets: how the corona virus is impacting education
Professor of Ecotoxicology Martina Vijver had planned an eight-week field work course for her students, but the corona virus threw a spanner in the works and Vijver had to come up with a new plan at short notice. ‘Without the help of my own network and that of my colleagues this would have been very…
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A unique defence: Bacteria lose cell wall in the presence of virus
Bacteria temporarily live without their cell wall if dangerous viruses are near. A remarkable feature, as the cell wall is a sturdy barrier against threats. Still, the discovery has a logical explanation ánd might be of a consequence for fighting pathogenic bacteria, according to Véronique Ongenae,…
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Organ failure caused by viruses, how does it work? Now there are methods to find out
Dying from viral infection due to organ failure and blood loss: we still know little about how it can happen. Among other things, Huaqi Tang developed an organ-on-a-chip to figure it out. 'These technologies can offer unprecedented opportunities to fight the viruses that threaten our society.' Tang…
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Grant Elise Mathilde Fund & LUF: Using virus to kill bacteria: design of innovative phage-antibiotic combination treatments to combat antimicrobial
Phage therapy is a novel yet unmatured therapeutic approach in the face of the crisis of antimicrobial resistance (AMR). Dr. Tingjie Guo received a grant from the Elise Mathilde Fund and the LUF to develop innovative phage-antibiotic combination treatment strategy for combating AMR.
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Development of cross-protective influenza A vaccines based on cellular responses
Seasonal influenza vaccines provide protection against matching influenza A virus (IAV) strains mainly through the induction of neutralizing serum IgG antibodies. However, these antibodies fail to confer a protective effect against mismatched IAV. This lack of efficacy against heterologous influenza…
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Support the Rapidemic team and help them develop a mobile testing kit
A team of students from Leiden won the iGEM international biology contest in 2020 with their Rapidemic mobile testing kit. The kit makes it easy to detect viruses. The team has now been nominated for the Most Innovative Student in the Netherlands prize. Cast your vote and help them develop their inv…
- Old Observatory closed because of corona virus
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When will there be a coronavirus vaccine?
The genetic code of the new coronavirus has been found: it is closely related to the SARS virus from 2003. Professor of Molecular Virology, Eric Snijder, has been researching coronaviruses for years. We asked him a few questions about the outbreak. ‘It’s still unclear whether this new virus is more…
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Solid Bioneedle-Delivered Influenza Vaccines Are Highly Thermostable and Induce Both Humoral and Cellular Immune Responses
The potential of bioneedles to deliver influenza vaccines was investigated.
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VODAN Africa – FAIR Covid-19 Data across Africa and Asia
VODAN Africa started as a platform to enable access to critical data needed from Africa to fight the novel COVID-19. The initiative was inspired by the experience from the Liberia Ebola Virus outbreak in 2014: early detection requires contact tracing. Inclusion of the most vulnerable is critical to…
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Viral Vector Facility
The Viral Vector Facility produces batches of lentivirus and adenovirus for preclinical research within the LUMC. And it assists researchers to produce their own virus.
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Further Reading Materials
Please find below links to articles / events that might be of interest.
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Spherical mosaics from different tiles
What are 'defects' and mechanical properties of mosaics of different shapes of tiles?
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Fast vaccine design and development based on correlates of protection (COPs) Influenza as a trendsetter
New and reemerging infectious diseases call for innovative and efficient control strategies of which fast vaccine design and development represent an important element.
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The immune system in action against cervical cancer
In the hunt for a vaccine against cervical cancer, fundamental knowledge about the immune system and organic chemistry have been brought together and have already resulted in a vaccine that is now being tested in clinical trials. Scientists are now working hard on an improved variant.
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COVID-19 vaccine
Leiden researchers are helping develop safe COVID-19 vaccines.
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Defining optimal oncolytic virus treatment and diagnostics in high risk melanoma patients
PhD defence
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Global metabolomics and lipidomics approaches to probe virus-host interactions
PhD defence
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Risks and potential benefits of adoptively transferred virus-specific T cells
PhD defence
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clinical development for vaccines and therapeutics against respiratory virus infections
PhD defence
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Government Capacity, Societal Trust or Party Preferences? What Accounts for the Variety of National Policy Responses to the COVID-19 Pandemic
What Accounts for the Variety of National Policy Responses to the COVID-19 Pandemic in Europe?
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Unraveling the mysteries of Multiple Sclerosis
Leiden chemists discovered a new mechanism which might explain how multiple sclerosis shifts to a more severe form. Their findings contribute to unravelling the mysterious course of the disease. They have published their findings in the journal Biochemistry.
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Young Hae Choi
Associate professor at the Natural Products Laboratory, Institute of Biology, Leiden University - the Netherlands
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Nuclear magnetic resonance force microscopy at millikelvin temperatures
Promotor: T.H. Oosterkamp
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Improved storage stability and immunogenicity of hepatitis B vaccine after spray-freeze drying in presence of sugars
The current hepatitis B vaccines need to be stored and transported under refrigerated conditions (2-8 degrees C). This dependence on a cold-chain is highly challenging in areas where hepatitis B virus infections are endemic.
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Don't believe it! A global perspective on cognitive reflection and conspiracy theories about COVID-19 pandemic
Together with two other authors, Jaroslaw Kantorowicz from ISGA investigates the susceptibility to believing in misinformation.
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Formulation of influenza T cell peptides: In search of a universal influenza vaccine
Promotoren: G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij
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Antibody-mediated delivery of viral epitopes to redirect virus-specific CD8+ T cells to cancer cells
PhD defence
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Non-target effects of GM potato: an eco-metabolomics approach
Promotors: Prof.dr. P.G.L. Klinkhamer, Prof.dr. P.M. Brakefield
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National identity predicts public health support during a global pandemic
Honorata Mazepus and Jaroslaw Kantorowicz are assistant professors at the Institute of Security and Global Affairs. Mazepus and Kantorowicz are one of the authors of this article in Nature on the role of national identity on public health support during global pandemics.
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Novel Hollow Microneedle Technology for Depth-Controlled Microinjection-Mediated Dermal Vaccination: A Study with Polio Vaccine in Rats
PURPOSE: The aim of the study was to develop a cheap and fast method to produce hollow microneedles and an applicator for injecting vaccines into the skin at a pre-defined depth and test the applicability of the system for dermal polio vaccination.
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Self adjuvanting immunopeptides: Design and synthesis
Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.
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Centre for Microbial Cell Biology
The CMCB brings together microbial cell biology expertise in Leiden. It aims at optimal resonance between the groups and maximal exploitation of the available infrastructure and to develop innovative cross-boundary technology platforms.
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9 Ways Coronavirus Could Transform Capitalism
Natascha van der Zwan, Assistant Professor at Leiden Univeristy, together with two other authors, wrote a book that explored some of the ways coronavirus is impacting the global capitalist system – and how this could change for better and for worse.
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Testing vaccines without laboratory animals?
The quality of vaccines is still often tested by using laboratory animals. That has to change, according to researchers from Leiden University and the vaccinological institute Intravacc. Together they went searching for a test method that makes animal testing unnecessary. The first promising results…
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Honorary doctorates for Belgian virologist Marc van Ranst and German Arabist Beatrice Gründler
Leiden University is awarding an honorary doctorate to virologist Marc van Ranst. Van Ranst has been one of the main advisers of the Belgian government during the Covid pandemic. German Arabist Beatrice Gründler will also receive an honorary doctorate for her work in the field of Oriental Manuscript…