Molecular Physiology is a research group at the Leiden Institute of Chemistry dedicated to the design, synthesis and application of chemical tools to study important biological and biomedical questions. The group is headed by Prof. Dr. Mario van der Stelt and includes the research lines of Assistant…

Therapeutic proteins have revolutionized the treatment of many severe diseases like multiple sclerosis, haemophilia, diabetes and many more. Unfortunately, even recombinant proteins with structures (almost) identical to those of their endogenous counterparts often induce the formation of anti drug antibodies…

The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.

The precise psychobiological mechanisms leading to chronic physiological stress responses have not been sufficiently explained, although stress is a major risk factor for disease and early death. A problem for conventional stress theory is that most of these responses seem to occur in situations without…

Lecture

A master's degree in Psychology at Leiden University combines theoretical knowledge with academic and professional skills, making you an attractive candidate for many employers.

How to reconstruct the middle parts (videlicet haute-contres, tailles and quintes) from French orchestral pieces, which survived only in their reduced forms (featuring primarely dessus and continuo), according to historical examples?

Suddenly getting lost, failing to recognise family members, or forgetting words and names are well-known symptoms of Alzheimer's disease. Psychologists have now discovered that the disease also manifests in more subtle ways: through the rhythm of finger tapping.

How do societies move forward with sustainable, effective and efficient management of Earth's water resources?

Farmers do not love them all. Microbes can cause tragic consequences for crops. Even the presence of just one pathogenic fungus or bacterium can drastically reduce yields. Still, there are exceptions. In that case, a pathogenic microbe is present in the soil, but does not cause any harm. Adam Ossowicki…

Gilles van Wezel of the Institute of Biology Leiden will lead a European consortium to search for new medicines and disease-suppressive microbes while preserving biodiversity. The consortium will explore the largely unknown potential of marine microorganisms.

The team of Alireza Mashaghi at the Leiden Academic Centre for Drug Research has found a way to determine and classify the shape of proteins. Their new theory defines the topology of proteins as a simple and precise barcode that allows the identification of all types of folds. ‘This barcode enables…

How De Haan is using language in general and his specific style of language in particular to provide truth, solidarity and justice for both the individual and the collective?

To what extent is sound a stressor to fish? And are behavioural and physiological phenotypes equally sensitive to disturbance by noise pollution?

PhD defence

Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra

A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.

Chromatin is an ubiquitous protein-DNA complex that forms the structural basis of DNA condensation in all eukaryotic organisms.

Biological polymers, including proteins and the genome, undergo folding processes crucial for their proper functioning. Even slight changes in the folding structure of these biopolymers can have significant implications, leading to the development of various pathological conditions, such as neurodegenerative…

Promotor: Prof.dr. J.P. Abrahams

Assistant Professor at the Metabolomics group, LUMC, The Nederlands

This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.

Research in the Jawerth lab focuses on using principles from soft condensed matter physics to understand important biological materials.

Retrospection over the last 40 years the most important changes in care and research, where transparency accountability and guidelines became leading. On Huntington’s disease and cerebrovascular disorders the most important changes are illustrated.

Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

The Therapeutic Immunomodulation Group is led by Prof. Johan Kuiper. In this group we aim to identify novel immunologic targets and apply immunotherapy to inhibit or even prevent the development of atherosclerosis.

Atopic eczema is a skin disease with increasing incidence currently affecting 25% of the paediatric population. In atopic eczema the skin barrier function is reduced. This barrier is formed by the outermost layer of the skin called the stratum corneum (SC). The SC consists of terminally differentiated…

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

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The research area of this division is focused on the development of novel therapeutic modalities and novel concepts in early drug discovery, in order to better predict ligand-target interactions.

The research of the Biotherapeutic Delivery group led by Joachim Van Guyse focuses on developing novel polymer-based formulations for therapeutic nucleic acid and protein delivery. The research revolves around developing structure-activity relationships between the chemical structure of polymers, the…

Those who look ahead can see we build the future together.

The ‘Contagious!’ exhibition was set to open at Rijksmuseum Boerhaave in April but had to be postponed because of the corona crisis. The museum hasn’t been twiddling its thumbs in the meantime. The exhibition will now open on 16 July, and the corona crisis has a major role.

PhD defence

A Vici grant and a Science-GROOT: scientists from the Institute of Biology Leiden have been awarded prestigious grants from the Dutch Research Council (NWO). From investigating bacteria without cell walls to harnessing plants with the help of microorganisms.

Environmental scientist Rutger Hoekstra addressed the General Assembly of the United Nations on 12 April. And that’s quite a big thing to do. How do you get there as a scientist? And, more importantly, what was his message? In eight questions, Rutger explains what he does and why.

This book looks to existential thinkers for reasons to hope immortal life could be worth living. It injects new arguments and insights into the debate about the desirability of immortality, and tackles related issues such as boredom, personal identity, technological progress, and the meaning of life…

We are a dynamic research group at the Leiden Institute of Physics. Our aim is to explore and understand quantum materials, including strange metals, high-temperature superconductors, and quantum critical electron matter.

The emissions of the Chinese industrial sector alone comprise 24.1% of global emissions (7.8 GtCyr−1 in 2015). This makes Chinese industrial emissions of unique national and international relevance in climate policy. This study reports a literature survey that quantitatively describes the evolution…

This book explores how physicists, astronomers, chemists, and historians in the late nineteenth and early twentieth centuries employed ‘epistemic virtues’ such as accuracy, objectivity, and intellectual courage. In doing so, it takes the first step in providing an integrated history of the sciences…

Slavoj Žižek is one of the most prominent public intellectuals of the left. His central claim holds that “today, it is more crucial than ever to continue to question the very foundations of capitalism as a global system”.

Although graduate schools and PhD programs at various Dutch universities do provide methodological training in the social sciences, PhD students in anthropology frequently express a need for more specialized anthropology courses that provide in-depth discussions of cutting-edge theory and state-of-the-art…

Dr Karolina Pomorska has been awarded the Jean Monnet Chair “EU and the World” for three years (2018-2021). Jean Monnet Chairs are teaching posts with a specialisation in European Union studies for university professors, awarded by the European Commission in a highly competitive peer-reviewed proces…

Sound & Score brings together music expertise from prominent international researchers and performers exploring the intimate relations between sound, score and notation, and the artistic possibilities that this relationship yields for performers, composers and listeners.

Associates of Leiden University Center for Intercultural Philosophy

This book focuses on policing in city-regions in Europe bringing together experts from across the continent to develop a sociology of urban policing and a unique methodology for comparing different metropolises in the same country.

International trade plays a critical role in global food security, with global consumption having highly localized environmental impacts.