How to reconstruct the middle parts (videlicet haute-contres, tailles and quintes) from French orchestral pieces, which survived only in their reduced forms (featuring primarely dessus and continuo), according to historical examples?

Gilles van Wezel of the Institute of Biology Leiden will lead a European consortium to search for new medicines and disease-suppressive microbes while preserving biodiversity. The consortium will explore the largely unknown potential of marine microorganisms.

To what extent is sound a stressor to fish? And are behavioural and physiological phenotypes equally sensitive to disturbance by noise pollution?

Despite recent advances in medicine, many devastating disorders like cancer and cardiovascular, neurodegenerative and infectious diseases still lack effective treatments. In order to address this challenge, we, as scientists from Leiden University, joined hands in the LED3 network. LED3, for Leiden…

The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.

Molecular Physiology is a research group at the Leiden Institute of Chemistry dedicated to the design, synthesis and application of chemical tools to study important biological and biomedical questions. The group is headed by Prof. Dr. Mario van der Stelt and includes the research lines of Assistant…

Therapeutic proteins have revolutionized the treatment of many severe diseases like multiple sclerosis, haemophilia, diabetes and many more. Unfortunately, even recombinant proteins with structures (almost) identical to those of their endogenous counterparts often induce the formation of anti drug antibodies…

From molecule, to cell, to organism. The high-level drug research at the Cell Observatory aimes at reducing the spread of cancer and developing new medicines for tuberculosis.

In the hunt for a vaccine against cervical cancer, fundamental knowledge about the immune system and organic chemistry have been brought together and have already resulted in a vaccine that is now being tested in clinical trials. Scientists are now working hard on an improved variant.

The precise psychobiological mechanisms leading to chronic physiological stress responses have not been sufficiently explained, although stress is a major risk factor for disease and early death. A problem for conventional stress theory is that most of these responses seem to occur in situations without…

Exploring the landscapes of mental health and cardiometabolic research.

Five talks will be given during the Leiden Science Family Day: two children's lectures and three lectures for adults. Will you be there ?

Through his project we will unravel the global regulatory networks that control gene expression in Streptomyces bacteria and allow them to properly respond to major changes in the environment; we will then harness this knowledge to activate and identify novel antibiotics

Supervisor: Anna Vlachodimou

A master's degree in Psychology at Leiden University combines theoretical knowledge with academic and professional skills, making you an attractive candidate for many employers.

Lecture

PhD defence

On June 7 Restless Horizon, a composition by Richard Barrett and Milana Zarić, premiered online.

How De Haan is using language in general and his specific style of language in particular to provide truth, solidarity and justice for both the individual and the collective?

The ‘Contagious!’ exhibition was set to open at Rijksmuseum Boerhaave in April but had to be postponed because of the corona crisis. The museum hasn’t been twiddling its thumbs in the meantime. The exhibition will now open on 16 July, and the corona crisis has a major role.

How do societies move forward with sustainable, effective and efficient management of Earth's water resources?

The team of Alireza Mashaghi at the Leiden Academic Centre for Drug Research has found a way to determine and classify the shape of proteins. Their new theory defines the topology of proteins as a simple and precise barcode that allows the identification of all types of folds. ‘This barcode enables…

A Vici grant and a Science-GROOT: scientists from the Institute of Biology Leiden have been awarded prestigious grants from the Dutch Research Council (NWO). From investigating bacteria without cell walls to harnessing plants with the help of microorganisms.

PhD defence

An inclusive society in which everyone has equal access to health and wealth is the focus of the new Leiden-Delft-Erasmus Centre on the Governance of Migration and Diversity. Professor of Migration History, Marlou Schrover, also works at the new centre. ‘It is important to add a historical perspective…

Retrospection over the last 40 years the most important changes in care and research, where transparency accountability and guidelines became leading. On Huntington’s disease and cerebrovascular disorders the most important changes are illustrated.

Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra

Chromatin is an ubiquitous protein-DNA complex that forms the structural basis of DNA condensation in all eukaryotic organisms.

A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.

Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

Biological polymers, including proteins and the genome, undergo folding processes crucial for their proper functioning. Even slight changes in the folding structure of these biopolymers can have significant implications, leading to the development of various pathological conditions, such as neurodegenerative…

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

Atopic eczema is a skin disease with increasing incidence currently affecting 25% of the paediatric population. In atopic eczema the skin barrier function is reduced. This barrier is formed by the outermost layer of the skin called the stratum corneum (SC). The SC consists of terminally differentiated…

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This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.

Assistant Professor at the Metabolomics group, LUMC, The Nederlands

Research in the Jawerth lab focuses on using principles from soft condensed matter physics to understand important biological materials.

The Therapeutic Immunomodulation Group is led by Prof. Johan Kuiper. In this group we aim to identify novel immunologic targets and apply immunotherapy to inhibit or even prevent the development of atherosclerosis.

Promotor: Prof.dr. J.P. Abrahams

The research of the Biotherapeutic Delivery group led by Joachim Van Guyse focuses on developing novel polymer-based formulations for therapeutic nucleic acid and protein delivery. The research revolves around developing structure-activity relationships between the chemical structure of polymers, the…

The research area of this division is focused on the development of novel therapeutic modalities and novel concepts in early drug discovery, in order to better predict ligand-target interactions.

Those who look ahead can see we build the future together.

Sylvia van Beugen has won the Herman Musaph Literature award 2016 for the best publication about psychodermatology. Her publication describes the importance of body awareness in chronic skin conditions, such as psoriasis.

During the 7th annual meeting of the Association for Researchers in Psychology and Health (ARPH) Sylvia van Beugen, from the Health, Medical and Neuropsychology unit, was awarded with the ’Best PhD Thesis Award’ for her dissertation ‘Psychodermatology 2.0: Towards improved assessment and effective digital…

The overall aim of the project is to investigate interests and their development over time in a daily life context, with particular attention for the transition from late secondary to post secondary education, and from late post secondary education to early career.

Environmental scientist Rutger Hoekstra addressed the General Assembly of the United Nations on 12 April. And that’s quite a big thing to do. How do you get there as a scientist? And, more importantly, what was his message? In eight questions, Rutger explains what he does and why.

Global versus local, democracy versus dictatorship, tradition versus modernisation: such contrasts make it difficult for anthropologists. They look in detail at what really happens and can therefore add some nuance to blueprints and debates, is what Frank Pieke, Professor in Modern China Studies, will…