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The aim of the REACT Study is to examine whether baseline inflammation, and/or neuro-immune responses to stress in a sample of adolescents with experiences of childhood adversity predicts: the perception of stress, social behaviour and general mental and physical health during and after the COVID-19…

A tantalizing concept that has emerged in our recent research is binding kinetics. An important parameter is residence time (RT), a direct reflection of how long a drug stays bound to its target. This parameter is of crucial importance, because drug action lasts only as long as the receptor-ligand complex…

VODAN Africa started as a platform to enable access to critical data needed from Africa to fight the novel COVID-19. The initiative was inspired by the experience from the Liberia Ebola Virus outbreak in 2014: early detection requires contact tracing. Inclusion of the most vulnerable is critical to…

The receptor nomenclature committee of IUPHAR, the International Union of Pharmacology, has several subgroups. Among these are a few that our division is involved in, those for adenosine, nicotinic acid, and GnRH receptors.

Our object is to identify and characterize transcription factors involved in lignocellulosic biomass degradation in the filamentous fungus Aspergillus niger.

The outbreaks of AIDS and COVID-19 showed clearly how infectious viruses can influence people’s lives. Investigating the changes in the host metabolism may provide a paradigm shift to consider immune-metabolic interactions as therapeutic targets.

Deze onderzoeksgroep richt zich op het thema ondermijning en financieel-economische criminaliteit, in het bijzonder de aanpak ervan op een aantal deelterreinen.

What Accounts for the Variety of National Policy Responses to the COVID-19 Pandemic in Europe?

How can mega sand nourishments, such as the Sand Motor, be designed and managed for optimal ecosystem services provision ?

Key publications of the Cardiovascular Pharmacology group

The project concerns the nature, the usages and functions of pictographic systems in relation to writing in societies with (restricted) literacy.

Target selectivity is an important aspect of any drug molecule, and certainly a parameter to be optimized. That is not trivial for a number of reasons. First of all hundreds of drug targets (receptors, enzymes, ion channels) exist, and no single lab in the world has assays for all of them.

The ambition of the Medical Systems Biophysics and Bioengineering group led by Alireza Mashaghi is to develop and use physics and engineering concepts and tools for pathophysiology, diagnostics and therapy.

Source: J Med Chem, Volume 57, Issue 8, pp. 3213-22 (2014)

Public leadership received increasing attention, but we still do not understand how the context of public leaders affects leadership. This research project delves into public leaders’ perceptions of the leadership situations they find themselves in, which are characterised by multiplicity – one could…

This dissertation takes an important step in understanding the phenomenon of non-take-up of social support and what it means for contemporary social policies.

Promotores: B.R. Katzy, J. de Vries, Co-Promotor: L.P. Groenewegen

Animal models suggest that the chemokine ligand 2/CC-chemokine receptor 2 (CCL2/CCR2) axis plays an important role in the development of inflammatory diseases. However, CCR2 antagonists have failed in clinical trials because of a lack of efficacy.

This dissertation describes the history of the Ottoman county of Foçateyn as a case study of the process of transition from the Ottoman Empire to nation states.

In the wake of the COVID-19 pandemic, the pressing question is how this global health emergency impacted the research agendas of the field of crisis and disaster science. This article reviewed contributions in ten important crisis and disaster journals in the two and a half years following the COVID-19…

This study aims to explore the use of a behavioral-design-based approach in simulating patient flow through EMTs. It provides a dynamic behavioral simulation model to assess the interactions between patients, staff members, and the related dynamic movements/interactions with the health care facility,…

In A History of Plague in Java, 1911–1942, Maurits Bastiaan Meerwijk demonstrates how the official response to the 1911 outbreak of plague in Malang led to one of the most invasive health interventions in Dutch colonial Indonesia.

This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.

The Covid-19 'infodemic' and conflict resolution by internet platforms.

Source: Eur J Med Chem (2015)

Promotor: J.M. van den Broek Co-promotor: M.C. de Vries

Annually the Institute of Cultural Anthropology and Development Sociology awards the Speckmann prize for the best Fieldwork NL report, as well as the most accomplished master’s thesis.

Designing and synthesizing high-affinity ligands for a given drug target have always been among the more important challenges in the drug discovery process.

The Faculty of Archaeology at Leiden is the leading academic institute for Archaeology in the Netherlands, and one of the largest in the world. The Faculty is an international front-runner, in the top ten of the QS World University Ranking, at subject level.

This study looks at population response to government containment strategies during initial stages of the COVID-19 pandemic in four high-trust Northern European countries–Denmark, Germany, the Netherlands, and Sweden–with special emphasis on expressions of governmental trust.

Agriculture is among the most vulnerable sectors to climate change and poorer countries face the most severe difficulties. Coffee farmers in Central America, for instance, are facing multiple and mutually reinforcing crises, including price shocks, outbreaks of pests and diseases, migration, and farm…

Drawing on insights from past and contemporary scholars and world leaders, the report explores the concepts of a new social contract, a new global deal, and networked and inclusive multilateralism introduced recently by Secretary-General António Guterres to help the United Nations better grapple with…

If you'll soon be getting a COVID-19 vaccine, you might just get the Johnson & Johnson (Janssen) one. This vaccine was developed for the most part in Leiden – and this is no coincidence. Watch the animation below about the development of one of the vaccines in the fight against COVID-19.

Allosteric modulation has long been recognized as a general and widespread mechanism for the control of protein function. Modulators bind to regulatory sites distinct from the active site on the protein, resulting in conformational changes that may profoundly influence protein function. This concept…

Although the world has made tremendous progress in health, education, sanitation and hygiene, global public health challenges still exist. Disparities in health exist between and within nations as evidenced by inequalities in disease burden, mortality, nutrition and environmental well-being. How does…

How to understand the simultaneously dis- and reappearance of letters in contemporary culture, and how does this Neo-Epistolarity relate to media-technological change?

What are ‘missing links’ in research on teacher professional development trajectories? We focus on the role and development of teacher facilitators in designing and implementing (collaborative) professional development trajectories.

Research question

What are the functions of autophagy in the filamentous fungus Aspergillus niger?

Now and then we organise book launches to present the latest publications, both academic and popular, in our broad field.

The Risk and Regulation Lab from organises events and workshops in Leiden and The Hague. On this page you can read reports of the events that already took place.

This dossier is for all members of our academic community who want to contribute to an open dialogue and wish to find out more about the context of the Israel-Palestine conflict.

The Mathematical Institute is responsible for the research and education in mathematics and statistics at Leiden University.

In 2023, many of our students and staff won great prizes and secured important research grants.

How can the Netherlands be better prepared for infectious diseases transmitted by mosquitoes. The Dutch Research Council (NWO) has awarded almost 9 million euros for this research. Maarten Schrama from the Institute of Environmental Sciences CML coordinates the input of Leiden University within the…

What are the goals of healthcare? That very question must be asked more frequently before healthcare-related choices are made. This is what Martine de Vries, Professor of Normative Aspects of Medicine, advocated during her inaugural lecture on Friday, 2 November 2018.

Key publications of the Predictive Pharmacology group.

This functional genomics project aims at understanding the biology of the underlying mycelium differentiation and autolysis processes in much more detail.