The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

We aim to develop a microfluidic platform that can parallelize testing the performance and characteristics of pure, mixed and environmental bacteriophage samples.

Promotor: Prof.dr. G.P. van Wezel

On 15 June 2023, the book presentation for the ‘Panta Rhei: recht en duurzaamheid’ (Panta Rhei: law and sustainability) was held at the Oude Sterrenwacht in Leiden. The book provides an overview of research in the field of sustainability conducted at Leiden Law School and was compiled by Yvonne Erkens,…

Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?

Recently the book “Privaatrecht 2050. De weg naar ecologische duurzaamheid” is published.

This research cluster explores processes of cultural creation, reception and transformation within a wide range of societal contexts from the early Middle Ages until c. 1800.

The Organ Art of the first female German concert organist and Bremen Cathedral organist and

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Markus Davidsen defended his thesis on 16 October 2014

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

This year the PhDs of the institute had their traditional day out (uitje) to The Hague. The last two years they had stayed in Leiden, so The Hague already seemed like quite the adventure. Indeed, it seems almost that as time progresses and more and more archives become digitized, history PhDs slowly…

The American magazine WIRED recently published an article on ‘quantum-safe public key encryption’.

On Thursday the 17th of February, from 13h00-17h00, Chris Wickham (Oxford University) and Leslie Brubaker (University of Birmingham) will give two lectures at the Radboud University. This will be an in-person event, held at the Thomas van Aquinostraat 1, room 1.10.06 in Nijmegen. For those unable to…

Promotores: J. Kok, M. Chaudron (Chalmers University)

The making of sacrifices seems part and parcel of any elite sportsperson’s life. Remarkably, the insights that we find in the current literature in social sport studies are not able to make sense of the references to sacrifice in the data that emerged in the context of this study on the social significance…

n this PhD thesis, the recombination of different atomic lattices in stacked 2D materials such as twisted bilayer graphene is studied. Using the different possibilities of Low-Energy Electron Microscopy (LEEM), the domain forming between the two atomic layers with small differences is studied.

Promotor: Prof.dr. A.G.G.M. Tielens, Co-Promotor: J.B.R. Oonk

The aim of this study is to further develop the Open Science Monitor, which started as a pilot study.

Promotor: Prof.dr. E.F. Smets

What makes a good historian? When historians raise this question, as they have done for centuries, they often do so to highlight that certain personal attitudes or dispositions are indispensable or studying the past. Yet their vieuws on what virtues, skills or competencies historians need most differ…

Can we predict fluctuations in suicidal ideation in a person’s daily life, from hour to hour?

The ARTIVES project studies imaginaries of diversity portrayed by artists in Lisbon and Rotterdam in their films, performances and (oral) literature with the aim to explore their transgressive potential of opening up possibilities of thinking differently about migration-related diversity. Their stories…

The project seeks to explore the interplay of valuation and inequalities in science, using the interdisciplinary and planet-critical field of forest research as empirical case. It examines which/whose knowledge is recognised on what grounds, and how social dimensions like gender and geographical location…

This thesis describes a study from both a theoreticaL and an experimental point of view.

In recent years, the use of primary data in terrorism research has increased. In order to maximise the benefits of this trend, we want to encourage terrorism scholars to implement open science practices more systematically. This article therefore presents different avenues towards open and reproducible…

In this article, Lianne Visser contributed to the understanding of why collaborative governance is a challenging response to wicked problems.

As part of Nexus 1492 Subproject 4: A Future for Diverse Caribbean Heritages, which seeks to shed light on how local communities interpret and engage with heritage in the present day, this doctoral study aims to gain insight into how indigenous heritage is represented in the school curriculum for social…

In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

Promotor: Prof.dr. R.M.H. Merks

The infectious diseases malaria and tuberculosis are responsible for 2.1 million deaths every year. Leiden researchers are currently testing a new tuberculosis vaccine.

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

In the studies described in this study, we introduce a novel ex vivo human skin barrier repair model. To develop this, we removed the upper layer of the skin, the stratum corneum (SC) by a reproducible cyanoacrylate stripping technique.