Overkleeft

Open access, online talks on African Sign Language Studies, in International sign and English

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

The researchers at the Institute of Education and Child Studies focus on child rearing and the development of children and adolescents with and without developmental and other problems, in biological and non-biological families, childcare, education and care institutions.

Social anxiety runs in families, but the neurobiology underlying this genetic vulnerability is until now largely unknown. The unique Leiden Family Lab study on Social Anxiety Disorder (LFLSAD) aims to broaden our knowledge with respect to this genetic susceptibility.

An overview is given of the flows of chlorine and chlorinated hydrocarbons through the Europian Union.

Promotor: Prof.dr. E.F. Smets, Co-promotores: Dr. B. Gravendeel, F. Pupulin

What is the role of neuronal emotional reactivity in the intergenerational transmission of abuse?

Thorough knowledge of practice is of great value to academic researchers in Education and Child Studies. This research master’s programme will train you to become a researcher who can contribute to resolving the challenges society currently faces, both within and outside academia. As a student, you…

Thorough knowledge of practice is of great value to academic researchers in Education and Child Studies. This research master’s programme will train you to become a researcher who can contribute to resolving the challenges society currently faces, both within and outside academia. As a student, you…

Alumni of LLM Advanced Studies programmes can request proof of graduation via Leiden Law School’s Office for International Education. This can take the form of a certified copy of your transcript, a confirmation of graduation letter or diploma verification by email. Alternatively, you can request digital…

This open access volume surveys the state of the field to examine whether a fifth wave of deterrence theory is emerging. Bringing together insights from world-leading experts from three continents, the volume identifies the most pressing strategic challenges, frames theoretical concepts, and describes…

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

Nobuaki Murai defended his thesis on 24 January 2018.

Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

This dissertation investigates A'-dependencies in Standard German, Zurich German and Dutch where the dislocated constituent is indirectly, i.e. not transformationally, related to the position where it is interpreted. The analysis is carried out within the Principles & Parameters framework.

This dissertation focuses on a new field of artistic research in which a visual artist takes on the role of researcher. The main research question is whether performance art integrated in an ecumenical service, combined with artistic directions from the artist, can enhance the religious experience of…

In specialist organ literature a negative verdict is given on organs and organ specialists from the 1930’s. Did the same verdict apply to Johan van Meurs’ (1903-1986) work? Which role does Van Meurs’ collection of organ specifications play in the historical research on the organ?

Promotores: F.H.J. Redig, W.T.F. den Hollander

This project investigates the globalization and cultural mediation of palliative care practices, policies and discourses.

What is the cost of visual complexity? This dissertation sets out to determine the effect of the complexity of word formation on the legibility of Arabic and the role that vocalization plays in reading.

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

Promotor: Prof.dr. B. van de Water, Co-promotor: L.S. Price

Combined hormonal contraceptives (CHC) are associated with an increased risk of venous thromboembolism (VTE). In 2013, a review was published by the European Medicines Agency (EMA). In this review, the authors concluded that the risk of VTE varies by the type of progesterone in the CHC. Subsequently,…

On the 12th of November, Xander Vertegaal successfully defended a doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Xander on this achievement!

On the 12th of December, Eleanor Dutton successfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Eleanor on this achievement.

The Centre for the Study of Political Parties and Representation (CSPPR) aims to serve as an interdisciplinary platform for scholars of Leiden University for research focusing on the historical and contemporary operation and functioning of political parties and political representation, with a particular…

From 1 August 2018, Alanna O'Malley was appointed as Chair of United Nations Studies in Peace and Justice, focusing on the ‘lesser-known actors’ of the UN: women, the youth, the agents of informal diplomatic networks within the UN and actors from the Global South. This Special Chair has been created…

How is social cognition shaped by our knowledge of language and stories?

In this thesis, the research focuses on the properties of dark matter and dark matter haloes and how they connect with the galaxies we can observe in the Universe.

This thesis attempts to establish a dialogue between the modern and the medieval traditions in logic, by means of ‘translations’ of the medieval logical theories into the modern framework of symbolic logic, i.e. formalizations.

The death of his grandfather in 1988 motivates Changsheng Wu to become a scientist. In 2016, he is awarded the C.J. Kok Jury Award for his thesis on novel antibiotics. Two years later, he will become a Professor at Shangdong University, at the age of 30 years.

Promotor: M. Ubbink, Co-promotor: G. Siegal

Science, Institute of Biology Leiden (IBL)

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

We aim to develop a microfluidic platform that can parallelize testing the performance and characteristics of pure, mixed and environmental bacteriophage samples.

Promotor: Prof.dr. G.P. van Wezel

Increasing resistance and a lack of new antibiotics are a serious problem for public health. Against this background, Gilles van Wezel of the Institute of Biology Leiden is looking for new medicines. Together with former PhD student Changsheng Wu and colleagues he discovered the special antibiotic lugdunomycin,…

Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?

This research cluster explores processes of cultural creation, reception and transformation within a wide range of societal contexts from the early Middle Ages until c. 1800.

The Organ Art of the first female German concert organist and Bremen Cathedral organist and

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Markus Davidsen defended his thesis on 16 October 2014

Writing with Light Magazine. Issue no.1 is now available for download as a open access pdf/interactive edition or purchase as limited-run print edition. The magazine builds on our prior work with the journals Cultural Anthropology and Visual Anthropology Review and the editorial collective consists…

Students who also want to develop their artistic talents can take a year-long art class – Practicum Artium – at the Royal Academy of Art in The Hague. ‘I can express my creativity and am learning to approach subjects in a visual way.’

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…