The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

Alumni of LLM Advanced Studies programmes can request proof of graduation via Leiden Law School’s Office for International Education. This can take the form of a certified copy of your transcript, a confirmation of graduation letter or diploma verification by email. Alternatively, you can request digital…

This open access volume surveys the state of the field to examine whether a fifth wave of deterrence theory is emerging. Bringing together insights from world-leading experts from three continents, the volume identifies the most pressing strategic challenges, frames theoretical concepts, and describes…

Overkleeft

An overview is given of the flows of chlorine and chlorinated hydrocarbons through the Europian Union.

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

Nobuaki Murai defended his thesis on 24 January 2018.

This dissertation investigates A'-dependencies in Standard German, Zurich German and Dutch where the dislocated constituent is indirectly, i.e. not transformationally, related to the position where it is interpreted. The analysis is carried out within the Principles & Parameters framework.

This article presents two related arguments. First, the limits of doctrinal analysis cut deeper than many EU lawyers realise. Most would probably accept that legal doctrine does not determine every legal dispute, but lawyers studying EU institutional balance often still assume that it can be deduced…

Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

How is social cognition shaped by our knowledge of language and stories?

Promotores: F.H.J. Redig, W.T.F. den Hollander

This project investigates the globalization and cultural mediation of palliative care practices, policies and discourses.

In specialist organ literature a negative verdict is given on organs and organ specialists from the 1930’s. Did the same verdict apply to Johan van Meurs’ (1903-1986) work? Which role does Van Meurs’ collection of organ specifications play in the historical research on the organ?

From 1 August 2018, Alanna O'Malley was appointed as Chair of United Nations Studies in Peace and Justice, focusing on the ‘lesser-known actors’ of the UN: women, the youth, the agents of informal diplomatic networks within the UN and actors from the Global South. This Special Chair has been created…

This research cluster explores processes of cultural creation, reception and transformation within a wide range of societal contexts from the early Middle Ages until c. 1800.

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

The Centre for the Study of Political Parties and Representation (CSPPR) aims to serve as an interdisciplinary platform for scholars of Leiden University for research focusing on the historical and contemporary operation and functioning of political parties and political representation, with a particular…

Promotor: Prof.dr. B. van de Water, Co-promotor: L.S. Price

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

On the 12th of November, Xander Vertegaal successfully defended a doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Xander on this achievement!

Combined hormonal contraceptives (CHC) are associated with an increased risk of venous thromboembolism (VTE). In 2013, a review was published by the European Medicines Agency (EMA). In this review, the authors concluded that the risk of VTE varies by the type of progesterone in the CHC. Subsequently,…

What is the cost of visual complexity? This dissertation sets out to determine the effect of the complexity of word formation on the legibility of Arabic and the role that vocalization plays in reading.

On the 12th of December, Eleanor Dutton successfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Eleanor on this achievement.

In this thesis, the research focuses on the properties of dark matter and dark matter haloes and how they connect with the galaxies we can observe in the Universe.

This thesis attempts to establish a dialogue between the modern and the medieval traditions in logic, by means of ‘translations’ of the medieval logical theories into the modern framework of symbolic logic, i.e. formalizations.

Op 2 oktober 2023 zullen meerdere nieuwe delen in de reeks Middeleeuwse Verzamelhandschriften uit de Nederlanden worden gepresenteerd, ditmaal uitsluitend in digitale vorm.

“Het is niet genoeg dat Amerika aanwezig is in de ruimte. Amerika moet domineren”, zegt Donald Trump tijdens een bijeenkomst met de Nationale Ruimteraad. Zodoende wil hij naast de land-, zee-, en luchtmacht een nieuwe militaire kracht oprichten: de Space Force. Ruimterecht deskundige Tanja Masson denkt…

This year, the National Clean-up Day, in an adapted form, will take place. Join us and take a clean-up walk on Saturday, March 20.⠀

Michiel Claessen, Ineke van der Ham, Nicolien de Rooij and Anne Visser have published a paper in the Nederlands Tijdschrift voor revalidatiegeneeskunde, (Dutch Journal of Rehabilitation Medicine) entitled ‘De weg kwijt na een beroerte: screening, diagnostiek en behandeling’.

Promotor: M. Ubbink, Co-promotor: G. Siegal

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?