Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

Psycho-physiological studies for health and disease.

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

Memory loss and confusion are signs of Alzheimer’s disease. Physicists Serge Rombouts and Martina Huber have developed new methods to help medical science get to the bottom of this insidious disease.

Overview of the main research projects at the Leiden Papyrological Institute.

On 8 November, Jordi Wiersma defended the thesis 'Democratie, deugden, docentschap: de docent als gids in de democratie'. The doctoral research was supervised by Andreas Kinneging and Paul van Geest.

Debate

The Faculty of Science adopted an action plan Diversity and Inclusiveness in 2015. In this action plan, the Faculty commits to a number of actions to further improve diversity and inclusion for staff and students, such as more female full professors at the faculty, and encourages initiatives that foster…

A new therapy for the serious Graft-versus-Host disease

The Repository from the Drug Disease Model Resources (DDMoRe) consortium provides a home to a collection of computational models of disease and drug action that have been used in pharmaceutical and/or academic research. This publically available open-access resource will make it easier for researchers…

Physics and Engineering Approaches to Biomedicine and Pharmacology

In autoimmune diseases such as rheumatism and diabetes the immune system attacks autologous proteins. Leiden researchers are trying to discover how this comes about.

PhD defence

Chemical biologists from Leiden, led by Dr Mario van der Stelt, have discovered substances that can reduce inflammation processes in the brain. This is a first step in the development of potential medicines for the treatment of brain diseases like Alzheimer's and Parkinson's. Published in Proceedings…

The central aim is to systematically study differences in gendered crime patterns in the records of different types of courts in various Dutch cities in the early modern period.

This project aims to assess the risk of spread of antimicrobial resistance genes in the environment derived from currently used synthetic biology approaches in the field of drug discovery.

Efficient gene-targeting during meiosis

The latest news on diversity and inclusion and an overview of coming D&I-activities within Leiden University.

The Institute of Biology Leiden (IBL) is an internationally oriented institute for research and education in biology.

We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.

Lizzy van Dorp enrolled at Leiden University in 1893 to study Literature. But the ambitious student changed path and became the first woman in the Netherlands to study law.

The experiences of ethnic ‘Other’ females have – until recently – been widely overlooked in the study of sport. There continues to be a need to produce critical scholarship about ethnic 'Other' girls and women in sport and physical culture, in order to represent their complex, multifarious and dynamic…

In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…

Many dangerous diseases such as COVID-19, Ebola and Q fever have jumped from animals to humans. But it is not only because of these diseases that we should include animals in our health policy, but also because of their right to health.

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

Our research is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.

The loss of T-cell homeostasis and tolerance towards self-antigens is the underlying cause of autoimmune and inflammatory diseases like atherosclerosis, rheumatoid arthritis or type I diabetes. Traditionally, the treatment of these diseases consisted on systemic immune suppression, which can entail…

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

Our immune system protects us against disease, but every now and then, something goes wrong: an enemy invades our bodies or our immune system attacks our own cells and we become ill. Doctors and researchers at the Leiden University Medical Center (LUMC) want to be able to manipulate the immune system…

Postdoc Lucia Bossoni has received an NWO Veni grant to research brain diseases for the next three years. She will work in labs at both the LUMC and the Leiden physics institute.

Why are mycobacteria such successful pathogens? And are there defence mechanisms in the body that help reduce an infection? To find out, Annemarie Meijer has been awarded the NWO Open Competition ENW-XL grant. She will not explore this quest alone. Five other leading Dutch research groups are participating…

Lecture, INVISIHIST event

This year it is 40 years ago that LOVA was established, which we want to celebrate with a seminar around the theme “Gender Moves”. We invite you to join us on May 10, 2019, at Leiden University, to explore how gender is enacted and reproduced in movement and how gendered movement contributes to dismantling…

From Incident to Precedent

From 1550 onwards, a great interest in the natural world developed across Europe. This interest was not only stimulated by a growing knowledge of local flora and fauna, but also by the import of numerous exotic animal and plant species. Think, for instance, of researches and collectors like Gessner…

The International Labour Organisation (ILO) was established in 1919 based on the premise that social justice is a condition for lasting peace. On February 2019 the ILO celebrated its 100th anniversary with an international symposium to consider the future of the ILO.

Mashaghi lab conducts research at the interface of physics, engineering and biomedicine. We develop and use theoretical and experimental approaches to address basic and applied research problems.

Α-synuclein, a protein associated with Parkinson’s disease, proves to bind with membranes in a surprisingly efficient way. It confirms scientists’ suspicion of the protein’s leading role in the transmission of neurotransmitters between nerve cells in the brain. Publication in PLoS ONE.

Cells in our bodies are often threatened by errors in our own proteins. The FLOW consortium, comprising scientists from various institutions including Leiden, is poised to meticulously map out for the first time how cells control proteins, correcting or removing faulty ones. This endeavour holds promise…

In the future, physicians may be able to identify dementia much earlier than they can today because a computer algorithm will be able to predict from brain scans how our memory is going to develop.

To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.

This research group, headed by Miranda van Eck, focusses on understanding the molecular mechanisms underlying cardiovascular and metabolic diseases. Cardiovascular disease constitutes a major health issue worldwide. Although significant knowledge has been obtained on the development of atherosclerotic…

The Leiden University Medical Center (LUMC) is committed to improving healthcare and the health of individuals. The LUMC staff put this mission into practice on a daily basis with their leading research, cutting-edge teaching and optimal, innovative healthcare.

Regenerative medicine is a new way of treatment that helps impaired cells, tissues, and organs work well again. We do this by repairing, replacing, or restoring cells, tissues, and organs after damage from illness or injury. This includes treating long-term diseases such as diabetes, kidney diseases,…