This project aims to assess the risk of spread of antimicrobial resistance genes in the environment derived from currently used synthetic biology approaches in the field of drug discovery.

Efficient gene-targeting during meiosis

From Incident to Precedent

From 1550 onwards, a great interest in the natural world developed across Europe. This interest was not only stimulated by a growing knowledge of local flora and fauna, but also by the import of numerous exotic animal and plant species. Think, for instance, of researches and collectors like Gessner…

The International Labour Organisation (ILO) was established in 1919 based on the premise that social justice is a condition for lasting peace. On February 2019 the ILO celebrated its 100th anniversary with an international symposium to consider the future of the ILO.

Lecture, INVISIHIST event

Since my master's thesis on the landed property of the Frisian monasteries in the Middle Ages I am highly interested in the do ut des-aspects of the relation between religious houses and the lay world. Key words here are: property, power, patronage and the role of religious institutions in the 'salvation…

This study interrogates contemporary and historical uses of barbarism, arguing that barbarism also has a disruptive, insurgent potential.

Inspired by a critical reconsideration of current monolithic approaches to the study of Greek religion, this book argues that ancient Greeks displayed a disquieting capacity to validate two (or more) dissonant, if not contradictory, representations of the divine world in a complementary rather than…

Religion, Class, and the Postwar Development of the Dutch Welfare State. Dennie Oude Nijhuis.

In this article, Ben de Jong, research fellow at the Institute of Security and Global Affairs, examines the relationship between double agents and their handlers.

Representing Japanese Colonial 'Heritage' in Taiwan

This paper aims to understand the most common underlying problems causing strategic surprise in the context of the European Union.

Until the 1990s, the only known planets were those in our Solar System. Three decades later, several thousand exoplanets have been discovered orbiting stars other than the Sun, and substantial efforts have been made to explore these strange new worlds through spectroscopic analyses of their atmosphe…

The project ‘Founding an Inclusive Space’ investigates the histories of various LGBT+ archives in the Netherlands, Germany and the United Kingdom.

Promotor: Prof.dr. M.K. Richardson, Co-Promotor: F. Witte

This project suggests a reconceptualisation of pre- and non-capitalist imperial monetary policy, arguing that the existing literature about imperial financial flows has unnecessarily privileged ideas of largesse and seemingly chaotic monetary distribution. Using the divergent cases of the Roman Empire…

Postdoc Lucia Bossoni has received an NWO Veni grant to research brain diseases for the next three years. She will work in labs at both the LUMC and the Leiden physics institute.

Mashaghi lab conducts research at the interface of physics, engineering and biomedicine. We develop and use theoretical and experimental approaches to address basic and applied research problems.

Why are mycobacteria such successful pathogens? And are there defence mechanisms in the body that help reduce an infection? To find out, Annemarie Meijer has been awarded the NWO Open Competition ENW-XL grant. She will not explore this quest alone. Five other leading Dutch research groups are participating…

Through a lens that examines the intersection of ageing, gender, class, and migration, this project addresses the “care deficit” in European countries and the employment of migrant women from Latin America to fill this deficit.

Through a lens that examines the intersection of ageing, gender, class, and migration, this project addresses the 'care deficit' in European countries and the employment of migrant women from Latin America to fill this deficit.

‘Going Beyond Gender’ reveals how diverse women's experiences and backgrounds can be and how this diversity can affect their opportunities and career in academia. The entire film was recorded in and around the Kamerlingh Onnes Building as well as the Academy Building. The five women featured in the…

In the future, physicians may be able to identify dementia much earlier than they can today because a computer algorithm will be able to predict from brain scans how our memory is going to develop.

This research group, headed by Miranda van Eck, focusses on understanding the molecular mechanisms underlying cardiovascular and metabolic diseases. Cardiovascular disease constitutes a major health issue worldwide. Although significant knowledge has been obtained on the development of atherosclerotic…

To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.

Regenerative medicine is a new way of treatment that helps impaired cells, tissues, and organs work well again. We do this by repairing, replacing, or restoring cells, tissues, and organs after damage from illness or injury. This includes treating long-term diseases such as diabetes, kidney diseases,…

The Leiden University Medical Center (LUMC) is committed to improving healthcare and the health of individuals. The LUMC staff put this mission into practice on a daily basis with their leading research, cutting-edge teaching and optimal, innovative healthcare.

The rapid advances in imaging technology enable to see inside the body with ever increasing detail.

Conference

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: Dr. A. El Ghalbzouri

The effectiveness of the skin barrier underlies the outer layer of the skin: the stratum corneum (SC). However, in several skin diseases this barrier is impaired. In two inflammatory skin diseases, atopic eczema and Netherton syndrome, an increased level of monounsaturated fatty acids (MUFAs) has been…

Animal Sciences’ contribution to the Bioactive Molecules research theme includes research on molecules from natural sources, such as plants, insects, and snake venom, with the aim to identify novel anti-cancer, anti-inflammatory, anti-microbial, and anti-diabetic agents.

Both psoriasis and atheroslcerosis are diseases characterized by a chronic and systemic inflammatory profile with local lipid disturbances that alter the barrier function of the skin (psoriasis) and cause the development of atherosclerotic plaques (atherosclerosis).

Zebrafish is an excellent model organism for studying various human diseases. Due to opaqueness of the adult phase, in vivo studies are restricted to early embryonic stages. This raises the need for rapid sensitive and non-invasive in vivo imaging methods to follow developmental processes, not only…

Promotor: Prof.dr. R. Verpoorte, , Co-Promotor: Young Hae Choi

Research projects

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

This research investigates the impact of socioeconomic developments on the physical condition of medieval populations in Holland and Zeeland between AD 1000 and 1600 through the analysis of human skeletal remains from three archaeological sites.

Medical Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University. The section is headed by Prof. Dr. Hans Aerts.

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Α-synuclein, a protein associated with Parkinson’s disease, proves to bind with membranes in a surprisingly efficient way. It confirms scientists’ suspicion of the protein’s leading role in the transmission of neurotransmitters between nerve cells in the brain. Publication in PLoS ONE.

Cells in our bodies are often threatened by errors in our own proteins. The FLOW consortium, comprising scientists from various institutions including Leiden, is poised to meticulously map out for the first time how cells control proteins, correcting or removing faulty ones. This endeavour holds promise…

The Department of Archaeological Sciences seeks to achieve the highest standards of excellence in science-driven education and archaeological research across the globe and across all periods.

If an echo (or ultrasound) shows that a foetus has a heart or other defect, parents face difficult decisions. Then an idea of their child’s shorter and longer-term future is literally a matter of life and death. Haak will argue in her inaugural lecture that the cohort studies of rare diseases that are…

On the 15th of July Sawako Takemura successfully defended a doctoral thesis and graduated.

The central aim is examining gender differences in recorded crime, particularly in relation to interpersonal violence, in early modern Bologna.

This study is a critical discourse analysis of the misogynistic narratives shared by three incel violent extremists.

This research project studies the distribution and impact of medieval malaria in the Netherlands.