Memory loss and confusion are signs of Alzheimer’s disease. Physicists Serge Rombouts and Martina Huber have developed new methods to help medical science get to the bottom of this insidious disease.

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

In the Drug Research theme, we primarily work with rodents. Rodents, such as mice, are one of the most common laboratory animals. These small mammals are easily housed and exhibit a rapid rate of reproduction.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Control of infectious diseases poses continuous challenges for human health.

The ADAPTED (Alzheimer's Disease Apolipoprotein Pathology for Treatment Elucidation and Development) project is a major new initiative to investigate an area of Alzheimer's Disease (AD) research which has previously received little attention. The project aims to improve understanding of the function…

Ariadne Schmidt, Isabelle Devos and Julie de Groot provide you with refreshing insights concerning the study on urban singles in the period between 1200 and 1900.

Announcement of a new publication by Janneke Verheijen, lecturer at the Institute of Cultural Anthropology and Development Sociology.

In this article, Dimiter Toshkov aims to explains the gender gap in COVID-19 vaccination attitudes.

Debate

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

Psycho-physiological studies for health and disease.

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

The Repository from the Drug Disease Model Resources (DDMoRe) consortium provides a home to a collection of computational models of disease and drug action that have been used in pharmaceutical and/or academic research. This publically available open-access resource will make it easier for researchers…

On 8 November, Jordi Wiersma defended the thesis 'Democratie, deugden, docentschap: de docent als gids in de democratie'. The doctoral research was supervised by Andreas Kinneging and Paul van Geest.

Five research projects of the Institute for History have been selected for the Research Traineeship Programme 2016-2017. The programme was initiated by The Faculty of Humanities to offer motivated students the opportunity to develop themselves in academic research. In December the research trainees,…

Chemical biologists from Leiden, led by Dr Mario van der Stelt, have discovered substances that can reduce inflammation processes in the brain. This is a first step in the development of potential medicines for the treatment of brain diseases like Alzheimer's and Parkinson's. Published in Proceedings…

PhD defence

The Faculty of Science adopted an action plan Diversity and Inclusiveness in 2015. In this action plan, the Faculty commits to a number of actions to further improve diversity and inclusion for staff and students, such as more female full professors at the faculty, and encourages initiatives that foster…

PhD defence

This project aims to assess the risk of spread of antimicrobial resistance genes in the environment derived from currently used synthetic biology approaches in the field of drug discovery.

A new therapy for the serious Graft-versus-Host disease

The team of WIIS-Netherlands exists out of the board members and the advisory council.

Physics and Engineering Approaches to Biomedicine and Pharmacology

In autoimmune diseases such as rheumatism and diabetes the immune system attacks autologous proteins. Leiden researchers are trying to discover how this comes about.

Efficient gene-targeting during meiosis

Postdoc Lucia Bossoni has received an NWO Veni grant to research brain diseases for the next three years. She will work in labs at both the LUMC and the Leiden physics institute.

The central aim is to systematically study differences in gendered crime patterns in the records of different types of courts in various Dutch cities in the early modern period.

Why are mycobacteria such successful pathogens? And are there defence mechanisms in the body that help reduce an infection? To find out, Annemarie Meijer has been awarded the NWO Open Competition ENW-XL grant. She will not explore this quest alone. Five other leading Dutch research groups are participating…

The latest news on diversity and inclusion and an overview of coming D&I-activities within Leiden University.

Recent insolvency cases highlight the growing importance of cross-border insolvency matters in international transactions. To this end, many instruments have been introduced and implemented in recent years across the world. At this page we present a selection of relevant instruments in the field of…

Lizzy van Dorp enrolled at Leiden University in 1893 to study Literature. But the ambitious student changed path and became the first woman in the Netherlands to study law.

The experiences of ethnic ‘Other’ females have – until recently – been widely overlooked in the study of sport. There continues to be a need to produce critical scholarship about ethnic 'Other' girls and women in sport and physical culture, in order to represent their complex, multifarious and dynamic…

The Institute of Biology Leiden (IBL) is an internationally oriented institute for research and education in biology.

We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.

In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…

Many dangerous diseases such as COVID-19, Ebola and Q fever have jumped from animals to humans. But it is not only because of these diseases that we should include animals in our health policy, but also because of their right to health.

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

Our research is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.

The loss of T-cell homeostasis and tolerance towards self-antigens is the underlying cause of autoimmune and inflammatory diseases like atherosclerosis, rheumatoid arthritis or type I diabetes. Traditionally, the treatment of these diseases consisted on systemic immune suppression, which can entail…

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.