How do you fit two meters of DNA in a tiny compartment and at the same time are able to access the right parts of it at the right times?

Supervisor: Andrea Martella

The Netherlands X-omics Initiative is a new facility as part of the National Roadmap for Large-Scale Research Infrastructures. It is partly funded by NWO with a total budget of 40 million euro. The project started on September 2018 and will last for ten years.

Antimicrobial resistance (AMR) is the phenomenon that pathogens become insensitive to the antibiotics that we use against them. A growing number of pathogens is becoming resistant, with methicillin-resistant S. aureus (MRSA) as the most famous example. But while the threat of AMR represents a slow-moving…

Mechanobiology is a major area in biology, however, mechanics is currently a missing element in drug development pipelines. This has led to a high cost for the society. Mechanotoxicity of drugs often appears as a long-term side effect of drugs, and has led to removal of drugs from the market. Furthermore,…

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

Supervisor: Indira Nederpelt

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

A research goal for ABS is to develop miniaturized platforms for research in (stem)cell, in-vitro systems and application in clinical and preventive research. Combined with the high throughput, this development will make it possible to study the dynamics of pathogenesis in human and cellular models…

Research on this theme addresses the systemic risks faced by European societies and affecting the quality of life of European citizens.

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

M. Danhof, Co-promotor: O.E. Della Pasqua

The Leiden Institute of Chemistry organises and participates in several programmes for high school students and teachers.

In this research project, we aimed to obtain more insight in the role of mast cells in the immune driven disorders rheumatoid arthritis and atherosclerosis.

Agricultural foods naturally vary in their detailed internal structure. To facilitate early detection of health hazards due to contamination or disease, predict maturity and minimize wastage, it is critical to take into account the internal characteristics of each individual product, as these enable…

We are very happy to welcome you to spend a semester or year studying or doing an internship with us at the Leiden University Medical Center. Here you will find information on your course timetables and registration.

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

Leiden University and the city of The Hague are working closely together to increase the impact of our research and education in order to contribute as much as possible to the development of the city.

Microbial Sciences' contribution to the Bioactive Molecules research theme is to discover new bioactive molecules and enzymes and unravel their mechanisms of action, regulatory networks, and the (bio)synthetic pathways required for their production.

The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.

All research at Leiden University is organised into institutes. To do justice to the wide spectrum of research (and consequently teaching) that comes from these, you will find descriptions of all the Leiden institutes on these pages.

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

Dr. Foks obtained this fellowship for the project “Can promotion of efferocytosis induce regression of atherosclerosis?”, in which she aims to identify novel targets to promote regression of atherosclerosis. This research grant allows her to initiate independent research for the next three years.

In this research group, headed by Prof. Erik Danen, the aim is to unravel cellular signaling mechanisms in normal and diseased cells, with a long-standing interest in cell adhesion signaling. In complex multicellular organisms such as ourselves, a division of labor emerges where different tissues and…

Research on heredity and diseases is simply not possible without programmers. Curious about how you can use your IT and biology skills to deal with real-life sickness and health problems? If so, Bio-Informatics in Leiden could be something for you.

As a student of Bio-Pharmaceutical Sciences, you have a strong interest in drug development: from the onset of diseases to the effects of individual drugs in the body. Is that true for you? Then, Bio-Pharmaceutical Sciences might be the right study programme for you!

Between 1798 and 1813 successive regimes attempted to enforce a fundamental geographical and administrative redivision of the Netherlands. The provinces that had been sovereign states within the Republic of the United Netherlands for over two centuries were dissolved and replaced by ‘departments’, subordinate…

This project sets out to map, document and analyze instances of squatting in Leiden from 1970 to 1990, in order to set up an online Digital Archive of Squatting in Leiden. This archive will function as an online resource for academic research, as well as a starting point for public activities such as…

Plants could be regarded as small chemical factories, which produce chemical substances via photosynthesis. If we can imitate photosynthesis in an artificial system, we can make clean fuels and materials out of sunlight and CO2. Huub de Groot is very close to designing a system of this kind.

The Cleveringa chair was installed by Leiden University in memory of Professor Rudolph Pabus Cleveringa and the courage he demonstrated in November 1940 during the German occupation . It also commemorates the liberation of the Netherlands in 1945.

PhD defence

PhD defence

Through a lens that examines the intersection of ageing, gender, class, and migration, this project addresses the “care deficit” in European countries and the employment of migrant women from Latin America to fill this deficit.

Through a lens that examines the intersection of ageing, gender, class, and migration, this project addresses the 'care deficit' in European countries and the employment of migrant women from Latin America to fill this deficit.

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence