The two-years master’s specialisation System Biomedicine and Pharmacology at Leiden university focuses on predicting drug response with computational modelling, developing individualised therapies, and developing innovative analytical tools for personalised health strategies.

PhD candidate Maia Casna received an Incentive Prize from the Dutch Association for Physical Anthropology (NVFA). She was rewarded this honor for her innovative research into respiratory diseases and her talent for presenting her results to both academic and general audiences. ‘It feels really nice…

What are the functions of the endocannabinoid system?

The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…

The HOPES study is one of the largest investigations of this kind to date! By studying existing brain scans and data collected form over 4,000 14-25 year olds, the project team hopes to identify specific changes in the brain that make young people vulnerable to suicidal thoughts and behaviours.

Large numbers of children all over the world face significant health risks, such as infectious and chronic diseases, malnutrition, injuries and the consequences of natural disasters, protracted armed conflicts and poverty.

Deficiency of glucocerebrosidase (GBA) underlies Gaucher disease, a common lysosomal storage disorder. Carriership for Gaucher disease has recently been identified as major risk for parkinsonism. Presently, no method exists to visualize active GBA molecules in situ. We here report the design, synthesis…

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

Aim of the proposal is to develop lugdunomycin into a drug candidate able to treat infectious diseases caused by multi-drug resistant pathogens.

Assessing and implementing new diagnostics strategies for stratifying patients

The unit Health, Medical and Neuropsychology offers eduction and conducts research on related fields of Health, Medical and Neuropsychology.

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

This study aims to explore the use of a behavioral-design-based approach in simulating patient flow through EMTs. It provides a dynamic behavioral simulation model to assess the interactions between patients, staff members, and the related dynamic movements/interactions with the health care facility,…

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

The Horizon 2020 project Sybil-AA (Systems Biology of Alcohol Addiction) focuses on modeling and validating disease state networks in human and animal brains for understanding pathophysiology, predicting outcomes and improving therapy in alcohol addiction. Alcohol addiction, the most severe form of…

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Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterize and predict variation in treatment response and enhance translational drug development strategies.

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…

The aim of the research programme Systems Pharmacology lies in the development of personalised medicine strategies, and development of new systems-based approaches in translational and clinical pharmacology.

Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.

Decision support tool for cell therapy commercialization and business development

The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB2R, their selectivity, molecular mode of action and pharmacokinetic properties have…

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

The division of BioTherapeutics consists of the former divisions Biopharmaceutics and Drug Delivery Technology.

The European Lead Factory has been created with the ultimate goal to develop lead drug candidates to address neglected diseases including bacterial infections, psychiatric disorders and oncology.

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

The SNP genotyping line offers flexible genotyping for small and large projects at affordable price and high quality. The use as SNPs as molecular markers is very versatile and can be used for a wide variety of scientific questions ranging from paternity analysis, conservatuion genetis towards QTL…

We aim to provide new insights relating to the spectacular multi-cellular life cycle of streptomycetes and other actinobacteria.

How humans and rats cohabit the cityscape and what consequences this has for both sides of the conflict?

An overview of research projects at the Predictive Pharmacology group.

Investigating the contribution of interpreters, informants, hunters and guides in the making of colonial scientific knowledge.

This is the first special issue of any organisation studies journal on food labour. Why is this a big deal? In this Introduction, we argue that the field should pay much more attention to the agri-food system and the work that goes into producing, distributing and consuming foodstuff. Food is such an…

PHM offers you the tools to navigate through, and give direction to, the complex and changing health care landscape by using an interdisciplinary approach. Become the broker to improve health and societal outcomes for citizens and patients.

The thesis presents a new perspective on Giovanni Girolamo Kapsperger (ca.1580-1651), who is nowadays only famous for his works for theorbo and lute, his remarkable output of vocal music of all genres being still mostly neglected from musicologists and performers.

Understanding the nature, characteristics and function of the secular vocal intabulations and dances found in Italian printed keyboard sources in the 16th century

Using artificial intelligence to find new antibiotics. With that, researchers from Leiden University are nominated by magazine KIJK for the Best Tech-idea of 2021. From September 14 onwards people can vote to crown one of the nominees as the winner.

The opportunity to explore a new, exciting research topic. That is how Lennart Schada von Borzyskowski describes his successful application for the NWO XS grant. It comprises 50,000 euros, which the researcher from the Institute of Biology Leiden (IBL) will spend on investigating a more sustainable…

Street theatre, drama, poetry and a lot of science: Leiden's Rapenburg was the backdrop for the fifth Night of Art and Knowledge on Saturday 16 September. Many University buildings - from the Observatory to the Hortus - opened their doors to artists, scientists and a public curious to know more.

Promotor: Prof.dr. J.W.M. Frenken

Exhibition

Tuberculosis bacteria and other intracellular pathogens use cells of our immune system as Trojan horses to spread into tissues. Annemarie Meijer, professor of immunobiology, explains how research into innate defence mechanisms using zebrafish inspires novel strategies for infectious disease treatmen…

Metabolomics is a powerful tool that can provide a comprehensive insight into the complexity of human biology and the pathophysiology of diseases. By analyzing the metabolome, which refers to the complete set of small (endogenous) molecules (with a mass <1500 Da) present within a given biological system,…