3,430 search results for “paul 1991 1990 disease works” in the Public website
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Attacking tuberculosis bacteria: an interview with Mónica Varela
This summer postdoctoral researcher Mónica Varela from the Institute of Biology Leiden was awarded a Veni grant from the Dutch Research Council (NWO). Six questions about her project and hopes for the future.
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Osteoarchaeologist Maia Casna interviewed on a podcast
PhD candidate Maia Casna was a guest on the new episode of the Wetenschappelijke Wezens podcast. In it, Maia discusses her research on urbanisation and respiratory diseases while uncovering the intricacies of studying the human past and bones.
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Why don't drugs make it to the market?
How can we extend the drug residence time to combat diseases more effectively?
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Vertebrate automated screening technology (VAST)
How can you use robots and automatic recognition of microscopic images to test the effect of drugs exceptionally quickly?
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Aging and Immunity
The Aging and Immunity group is led by Dr. Amanda Foks. In this group we aim to investigate how aged immune cells contribute to atherosclerosis and identify novel therapeutic targets and strategies to extend health span and inhibit cardiovascular disease.
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Azafaros is valorizing a library of compounds
The company Azafaros was established in 2018 to translate innovative science from Leiden University and Amsterdam University Medical Center into novel disease-modifying treatment modalities for rare genetic metabolic disorders such as lysosomal storage diseases.
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Bioorthogonal Antigens as Tool for Investigation of Antigen Processing and Presentation
In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…
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Chemical biology of sphingolipids: fundamental studies and clinical applications
Overkleeft
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The Hague International Space Resources Governance Working Group
The development of space resource activities is happening now. In the absence of a clear framework to govern these activities, there is a need to examine the concepts that are being discussed in order to ensure that they meet existing treaty obligations regarding on-orbit operations and space resource…
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Analytical chemistry and biochemistry of glycosphingolipids: new developments and insights
Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…
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Rational Design of Athero-Protective Vaccines; Novel Vaccine Formulations and Alternative Routes of Administration
Atherosclerosis is a chronic inflammatory disease affecting millions of people world-wide.
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CoSTREAM: Understanding Stroke and Alzheimer
The Horizon 2020 project CoSTREAM aims to improve our understanding of the co-occurrence of stroke and Alzheimer’s disease. It has long been known that both diseases share underlying causes, but their exact interaction or link is not fully understood. CoSTREAM combines multiple factors to identify and…
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Translations of Greek Tragedy in the Work of Ezra Pound
Turning the tables on the misconception that Ezra Pound knew little Greek, this volume looks at his work translating Greek tragedy and considers how influential this was for his later writing.
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IBL Spotlight - Development and Disease
Lecture
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Law and peace in the work of Hans Kelsen
Law and peace in the work of Hans Kelsen. A re-evaluation of Kelsen’s legal philosophy: legal pacifism as tacit meaning of his Pure Theory of Law
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Research
Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…
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Narrating Queer Identities: Politics of Sexuality and Identity Construction in the Novels of James Purdy
In my research I am concerned with the possibility of a politics of sexuality without reverting to identitarian conceptions of sexuality. In a reading of the work of the American author James Purdy, I propose to move towards a politicizing of the concept of narrative identity as developed by the French…
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Tatiana Afanassjewa public lectures about physics
The Tatiana Afanassjewa-lecture series is a series of public talks in Dutch by Leiden physicists on wednesday evenings, intended for everyone with an interest in physics.
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Key Issues in Historical Theory
This book addresses the definition of history and how people are influenced by it.
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Ronsard and Du Bartas in Early Modern Europe
In the Brill series Intersections a new volume has been published, entitled Ronsard and Du Bartas in Early Modern Europe.
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Van der Heijden Chair Social Justice
On the occasion of prof Paul van der Heijden’s stepping down as Rector Magnificus and President of the Executive Board of Leiden University in 2013 the Chair bearing his name on Social Justice was established. It was a “farewell present” of the Leiden University to it’s Rector.
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Hermeneutics and the Humanities
Hermeneutics and the Humanities: Dialogues with Hans-Georg Gadamer / Hermeneutik und die Geisteswissenschaften: Im Dialog mit Hans-Georg Gadamer
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Early Christian Encounters with Town and Countryside
Early Christian Encounters with Town and Countryside - Essays on the Urban and Rural Worlds of Early Christianity.
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The Rise and Decline of an Iberian Bourgeoisie
The Rise and Decline of an Iberian Bourgeoisie is one of the first long-term studies in English of an Iberian town during the late medieval crisis. Focusing on the Catalonian city of Manresa, Jeff Fynn-Paul expertly integrates Iberian historiography with European narratives to place the city's social,…
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Digiuseppe & Poast, ‘Arms versus Democratic Allies’
In theory, states can gain security by acquiring internal arms or external allies. Yet the empirical literature offers mixed findings: some studies find arms and allies to be substitutes, while others find them to be complements. Political scientists Matthew Digiuseppe (Leiden University) and Paul Poast…
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Andrei Poama for PLOS ONE: Does suffering suffice?
Does suffering suffice? Andrei Poama, Assistant Professor at Leiden University, and Paul C. Bauer, research fellow at the Mannheim Centre for European Social Research, did an experimental assessment of desert retributivism. Their resulsts were published on April 20 on PLOS ONE.
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Slaving Zones. Cultural Identities, Ideologies, and Institutions in the Evolution of Global Slavery
In Slaving Zones: Cultural Identities, Ideologies, and Institutions in the Evolution of Global Slavery, fourteen authors—including both world-leading and emerging historians of slavery—engage with the ‘Slaving Zones’ theory.
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Writing the History of the Humanities: Questions, Themes, and Approaches
What are the humanities? As the cluster of disciplines historically grouped together as “humanities” has grown and diversified to include media studies and digital studies alongside philosophy, art history and musicology to name a few, the need to clearly define the field is pertinent.
- Programme
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Data-Driven Machine Learning and Optimization Pipelines for Real- World Applications
Machine Learning is becoming a more and more substantial technology for industry.
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Agrobacterium-mediated protein therapy for genome editing
Is translocation of nucleases possible via Agrobacterium T4SS and is it efficient enough for mutagenesis?
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Older Publications
Overview of the publications of the department of Industrial Ecology (1982-2015)
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Chilean Transition to Democracy, from 1990 to 2022 Plebiscite: Recent Historical Analysis in Comparative Perspective
Lecture, MAIR Seminar
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Publish or Perish: Religious Zaydi publishers in Yemen during the 1990s
Lecture, LUCIS What's New?! Series
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Frank Schaftenaar
Science
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Data Analytics and Management
Our group is part of the Metabolomics and Analytics Centre where we accompany the data from its acquisition all the way to the publication of identified associations and biomarkers for a range of human diseases. The generated data of the metabolic measurements are assessed using an in-house quality…
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Fundamental and translational medical biochemistry
Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…
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Leiden archaeologist works with Kazakhs on numismatic collections
In May of 2023, an agreement was signed between Leiden PhD candidate Jonathan Ouellet and General Director Onggar Akan of the A. Kh. Margulan Archaeological Institute in Almaty. The aim: a detailed study of the numismatic history of Southern Kazakhstan.
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'Migraine requires a gender-specific approach'
Migraine is a brain disease. If it were simple, we would have solved it already'. That is the title of the inaugural lecture delivered by Professor of Neurology Gisela Terwindt on Friday 3 June. In her speech she emphasises the importance of research into the differences between women and men with m…
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Revolutionizing plant protection strategies: Ding lab receives 2.4M grant to investigate plant immunity
Plant biologist Pingtao Ding, assistant professor at the Institute of Biology Leiden (IBL), has received a 2.4 million European grant from the European Research Council (ERC). This ERC Starting Grant for promising young researchers allows him to unravel the molecular mechanisms by which plants resist…
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Reducing the chronic disease burden in China
PhD defence
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Programme structure
The master's specialisation Health and Medical Psychology consists of three main parts: the mandatory and elective courses, a thesis and an internship.
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Making Environmental Regulation Work for the People
The project’s overall goal is to improve Indonesia’s environmental legal framework and its implementation by strengthening the regulatory capacity of the government, and by enhancing the capacity of CSOs and scholars to hold the government accountable for its regulatory performance.
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Metabolomics and Analytics Centre
The ambition of the Metabolomics and Analytics Centre led by Thomas Hankemeier is to develop innovative analytical strategies for metabolomics-driven health monitoring and systems biology studies. Understanding the intricate balance between health, disease and adaptation to challenges relies on the…
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Research with animals
At Leiden University, in both our biomedical and biological research, we use laboratory animals. Learn more about these specific areas of research and the goals we aim to achieve through these studies.
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Finding the cause of memory loss
Memory loss and confusion are signs of Alzheimer’s disease. Physicists Serge Rombouts and Martina Huber have developed new methods to help medical science get to the bottom of this insidious disease.
- Leiden Academic Centre for Drug Research
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Synthesis and application of glycans unique to S. Mansoni
Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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Drug research
In the Drug Research theme, we primarily work with rodents. Rodents, such as mice, are one of the most common laboratory animals. These small mammals are easily housed and exhibit a rapid rate of reproduction.